Gene Symbol | LTBR |
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Entrez Gene | 4055 |
Alt Symbol | CD18, D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3 |
Species | Human |
Gene Type | protein-coding |
Description | lymphotoxin beta receptor (TNFR superfamily, member 3) |
Other Description | lymphotoxin B receptor|tumor necrosis factor C receptor|tumor necrosis factor receptor 2-related protein|tumor necrosis factor receptor superfamily member 3|tumor necrosis factor receptor type III |
Swissprots | D3DUR2 P36941 B7Z1D2 F5GXE7 |
Accessions | BAD01488 CCA94576 EAW88801 EAW88802 P36941 AK027080 AK095418 BAG53051 AK128019 AK293187 BAH11468 BC026262 AAH26262 BX648074 DA679291 DC424721 DQ891995 ABM82921 DQ895185 ABM86111 L04270 AAA36757 L04489 XM_005253688 XP_005253745 XM_006718983 XP_006719046 NM_001270987 NP_001257916 NM_002342 NP_002333 |
Function | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. {ECO:0000269|PubMed:10799510, ECO:0000269|PubMed:8171323}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, HTLV-I infection, Viral carcinogenesis |
LTβR siRNA (h) - sc-40241 from Santa Cruz Biotechnology
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LTβR shRNA Plasmid (h) - sc-40241-SH from Santa Cruz Biotechnology
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LTβR shRNA (h) Lentiviral Particles - sc-40241-V from Santa Cruz Biotechnology
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Lymphotoxin beta R/TNFRSF3 RNAi - H00004055-R02 from Novus Biologicals
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MISSION® esiRNA - EHU155461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12819 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12819 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05829 from Sigma-Aldrich
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LTBR siRNA (Human) - CRH2744 from Cohesion Biosciences
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shRNA set against Human LTBR (NM_002342.2) - SHH335511 from Creative biogene
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Human LTBR siRNA - orb263246 from Biorbyt
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LTBR shRNA Plasmid (Human) - CHH2744 from Cohesion Biosciences
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LTBR miRNA 3'UTR clone - MiUTR3H-03785 from Creative biogene
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