Gene Symbol | TBRG1 |
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Entrez Gene | 84897 |
Alt Symbol | NIAM, TB-5 |
Species | Human |
Gene Type | protein-coding |
Description | transforming growth factor beta regulator 1 |
Other Description | nuclear interactor of ARF and MDM2 |
Swissprots | Q8TCS4 Q66ZJ6 Q8TEI4 Q53GJ5 Q3YBR2 Q69YS7 Q96SV0 |
Accessions | CAE89317 EAW67589 EAW67590 Q3YBR2 AK027527 BAB55177 AK027766 AK057749 BAB71559 AK074140 BAB84966 AK074594 AK222936 BAD96656 AL713631 CAD28450 AL831881 CAH10595 AY696294 AAU10523 BC018452 AAH18452 BC032312 AAH32312 BC041043 AAH41043 BC064392 BC073160 AAH73160 BC107428 BC109269 AAI09270 DA292015 DQ144542 AAZ76016 XM_005271709 XP_005271766 XM_005271711 XP_005271768 XM_011543040 XP_011541342 XR_428983 NM_032811 NP_116200 NR_016021 |
Function | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17110379}. |
Tissue Specificity | Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. {ECO:0000269|PubMed:17110379}. |
TBRG1 (C-18) - sc-162291 from Santa Cruz Biotechnology
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TBRG1 (N-22) - sc-130612 from Santa Cruz Biotechnology
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Anti-TBRG1 antibody - ab203276 from Abcam
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Anti-TBRG1 antibody - Aminoterminal end - ab71318 from Abcam
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Anti-TBRG1 antibody - C-terminal - ab178783 from Abcam
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Anti-TBRG1 Antibody (aa6-36) - LS-C98708 from LifeSpan Bioscience
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Anti-TBRG1 Antibody (N-Terminus) - LS-C135844 from LifeSpan Bioscience
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Anti-TBRG1 Antibody (aa172-221) - LS-C187244 from LifeSpan Bioscience
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TBRG1 Antibody - NBP1-79855 from Novus Biologicals
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TBRG1 Polyclonal Antibody - bs-4268R from Bioss
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Anti-TBRG1 (N-term) antibody produced in rabbit - SAB1300797 from Sigma-Aldrich
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Anti-TBRG1 (center) antibody produced in rabbit - SAB1300798 from Sigma-Aldrich
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TBRG1 Antibody - C-terminal region (ARP60646_P050) - ARP60646_P050 from Aviva Systems Biology
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TBRG1 antibody - N-terminal region (ARP60647_P050) - ARP60647_P050 from Aviva Systems Biology
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TBRG1 Antibody - N-terminal region (OAAB03472) - OAAB03472 from Aviva Systems Biology
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TBRG1-Antibody-N-term - AP6376a from Abgent, a WuXi AppTec company
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TBRG1 Antibody (OABF01435) - OABF01435 from Aviva Systems Biology
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TBRG1 antibody - 70R-20723 from Fitzgerald
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TBRG1 antibody - 70R-10136 from Fitzgerald
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TBRG1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-4268R-A350 from Bioss
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TBRG1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-4268R-A488 from Bioss
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TBRG1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-4268R-A555 from Bioss
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TBRG1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-4268R-A647 from Bioss
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TBRG1 Polyclonal Antibody, Cy3 Conjugated - bs-4268R-Cy3 from Bioss
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TBRG1 Polyclonal Antibody, Cy5 Conjugated - bs-4268R-Cy5 from Bioss
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