| Gene Symbol |
TBRG1
|
| Entrez Gene |
84897
|
| Alt Symbol |
NIAM, TB-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor beta regulator 1
|
| Other Description |
nuclear interactor of ARF and MDM2
|
| Swissprots |
Q8TCS4 Q66ZJ6 Q8TEI4 Q53GJ5 Q3YBR2 Q69YS7 Q96SV0
|
| Accessions |
CAE89317 EAW67589 EAW67590 Q3YBR2 AK027527 BAB55177 AK027766 AK057749 BAB71559 AK074140 BAB84966 AK074594 AK222936 BAD96656 AL713631 CAD28450 AL831881 CAH10595 AY696294 AAU10523 BC018452 AAH18452 BC032312 AAH32312 BC041043 AAH41043 BC064392 BC073160 AAH73160 BC107428 BC109269 AAI09270 DA292015 DQ144542 AAZ76016 XM_005271709 XP_005271766 XM_005271711 XP_005271768 XM_011543040 XP_011541342 XR_428983 NM_032811 NP_116200 NR_016021
|
| Function |
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17110379}.
|
| Tissue Specificity |
Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. {ECO:0000269|PubMed:17110379}.
|
