| Gene Symbol | Ube2a |
|---|---|
| Entrez Gene | 22209 |
| Alt Symbol | HHR6A, HR6A, Mhr6a |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2A |
| Other Description | RAD6 homolog A|ubiquitin carrier protein A|ubiquitin-conjugating enzyme E2 A|ubiquitin-conjugating enzyme E2A (RAD6 homolog)|ubiquitin-conjugating enzyme E2A, RAD6 homolog|ubiquitin-conjugating enzyme HR6A|ubiquitin-protein ligase A |
| Swissprots | Q9Z255 |
| Accessions | AAL49960 EDL28980 EDL28981 EDL28982 Q9Z255 AF089812 AAC64563 AF383148 AAK62984 AK133723 BAE21800 AK150417 BAE29541 AK153327 BAE31906 AK160527 BAE35845 AK160538 BAE35855 AK160545 BAE35862 AK163966 BAE37558 AK164074 BAE37614 BC026053 AAH26053 NM_019668 NP_062642 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA (By similarity). {ECO:0000250}. |
| Top Pathways | Ubiquitin mediated proteolysis |