Gene Symbol | Ube2a |
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Entrez Gene | 22209 |
Alt Symbol | HHR6A, HR6A, Mhr6a |
Species | Mouse |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2A |
Other Description | RAD6 homolog A|ubiquitin carrier protein A|ubiquitin-conjugating enzyme E2 A|ubiquitin-conjugating enzyme E2A (RAD6 homolog)|ubiquitin-conjugating enzyme E2A, RAD6 homolog|ubiquitin-conjugating enzyme HR6A|ubiquitin-protein ligase A |
Swissprots | Q9Z255 |
Accessions | AAL49960 EDL28980 EDL28981 EDL28982 Q9Z255 AF089812 AAC64563 AF383148 AAK62984 AK133723 BAE21800 AK150417 BAE29541 AK153327 BAE31906 AK160527 BAE35845 AK160538 BAE35855 AK160545 BAE35862 AK163966 BAE37558 AK164074 BAE37614 BC026053 AAH26053 NM_019668 NP_062642 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA (By similarity). {ECO:0000250}. |
Top Pathways | Ubiquitin mediated proteolysis |
UBC2 CRISPR/Cas9 KO Plasmid (m) - sc-423582 from Santa Cruz Biotechnology
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UBC2 HDR Plasmid (m) - sc-423582-HDR from Santa Cruz Biotechnology
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UBC2 Double Nickase Plasmid (m) - sc-423582-NIC from Santa Cruz Biotechnology
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UBC2 Double Nickase Plasmid (m2) - sc-423582-NIC-2 from Santa Cruz Biotechnology
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UBC2 CRISPR Activation Plasmid (m) - sc-423582-ACT from Santa Cruz Biotechnology
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UBC2 CRISPR Activation Plasmid (m2) - sc-423582-ACT-2 from Santa Cruz Biotechnology
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UBC2 Lentiviral Activation Particles (m) - sc-423582-LAC from Santa Cruz Biotechnology
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UBC2 Lentiviral Activation Particles (m2) - sc-423582-LAC-2 from Santa Cruz Biotechnology
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UBC2 siRNA (m) - sc-41678 from Santa Cruz Biotechnology
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UBC2 shRNA Plasmid (m) - sc-41678-SH from Santa Cruz Biotechnology
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UBC2 shRNA (m) Lentiviral Particles - sc-41678-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU020021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43797 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43797 from Sigma-Aldrich
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UBE2A siRNA (Mouse) - CRM4315 from Cohesion Biosciences
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UBE2A - MBS8240838 from MyBioSource
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shRNA set against Mouse UBE2A (NM_019668.3) - SHH438836 from Creative biogene
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shRNA set against Mouse Ube2a(NM_019668.3) - SHL110280 from Creative biogene
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Mouse UBE2A siRNA - orb283791 from Biorbyt
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UBE2A shRNA Plasmid (Mouse) - CHM4315 from Cohesion Biosciences
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UBE2A miRNA 3'UTR clone - MiUTR1M-12377 from Creative biogene
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