| Gene Symbol |
AP3B1
|
| Entrez Gene |
8546
|
| Alt Symbol |
ADTB3, ADTB3A, HPS, HPS2, PE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adaptor-related protein complex 3, beta 1 subunit
|
| Other Description |
AP-3 complex beta-3A subunit|AP-3 complex subunit beta-1|adaptor protein complex AP-3 subunit beta-1|adaptor-related protein complex 3 subunit beta-1|beta-3A-adaptin|clathrin assembly protein complex 3 beta-1 large chain
|
| Swissprots |
Q9HD66 O00580 O00203 Q7Z393 E5RJ68
|
| Accessions |
AAG01739 EAW95811 EAW95812 EAW95813 O00203 AK225908 AK291201 BAF83890 AK303300 BAG64374 AL708147 AY623424 AAT49048 BC020230 BC038444 AAH38444 BX538041 CAD97982 DA889915 DQ894915 ABM85841 EU176289 ABW03740 U81504 AAB61638 U91931 AAD03778 XM_005248618 XP_005248675 XM_005248619 XP_005248676 NM_001271769 NP_001258698 NM_003664 NP_003655
|
| Function |
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
|
| Subcellular Location |
Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:9151686, ECO:0000269|PubMed:9182526}.
|
| Top Pathways |
Lysosome
|
![Western Blot: AP3B1 Overexpression Lysate (Adult Normal) [NBL1-07583] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AP3B1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1188_AP3B1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07583-img0002.jpg)