AP3B1

Gene Symbol AP3B1
Entrez Gene 8546
Alt Symbol ADTB3, ADTB3A, HPS, HPS2, PE
Species Human
Gene Type protein-coding
Description adaptor-related protein complex 3, beta 1 subunit
Other Description AP-3 complex beta-3A subunit|AP-3 complex subunit beta-1|adaptor protein complex AP-3 subunit beta-1|adaptor-related protein complex 3 subunit beta-1|beta-3A-adaptin|clathrin assembly protein complex 3 beta-1 large chain
Swissprots Q9HD66 O00580 O00203 Q7Z393 E5RJ68
Accessions AAG01739 EAW95811 EAW95812 EAW95813 O00203 AK225908 AK291201 BAF83890 AK303300 BAG64374 AL708147 AY623424 AAT49048 BC020230 BC038444 AAH38444 BX538041 CAD97982 DA889915 DQ894915 ABM85841 EU176289 ABW03740 U81504 AAB61638 U91931 AAD03778 XM_005248618 XP_005248675 XM_005248619 XP_005248676 NM_001271769 NP_001258698 NM_003664 NP_003655
Function Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subcellular Location Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:9151686, ECO:0000269|PubMed:9182526}.
Top Pathways Lysosome

AP-3β (D-20) - sc-69447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AP-3β (N-15) - sc-13384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AP-3β (N-15)-R: sc-13384-R. Western blot analysis of AP-3β expression in non-transfected 293T: sc-117752 (A), human AP-3β transfected 293T: sc-114819 (B) and HeLa (C) whole cell lysates.

Anti-HPS2 antibody - ab118584 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118584, at 7.5 µg/ml, staining HPS2 in formalin-fixed, paraffin-embedded Human Breast tissue by Immunohistochemistry.

Anti-HPS2 antibody - ab22146 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-HPS2 antibody (ab22146) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ugLane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ug SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-AP3B1 Antibody (aa995-1095) - LS-C306278 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-AP3B1 Antibody - LS-C109531 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: Hep G2. 7.5% SDS PAGE. AP3B1 antibody diluted at 1:1000.

Anti-AP3B1 Antibody (aa2-14) IHC-plus™ - LS-B5108 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-AP3B1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5108 concentration 3.75 ug/ml.

AP3B1 Antibody - NBP1-68927 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AP3B1 Antibody [NBP1-68927] - Rat Liver lysate, concentration 0.2-1 ug/ml.

AP3B1 Antibody - NBP1-89228 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: AP3B1 Antibody [NBP1-89228] - staining of human cell line U-2 OS shows localization to nucleoplasm. Antibody staining is shown in green.

AP3B1 Antibody - NBP1-33723 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AP3B1 Antibody [NBP1-33723] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:1000.

AP3B1 Antibody (3B4) - H00008546-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B4

AP3B1 Antibody - H00008546-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

AP3B1 Antibody - H00008546-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: AP3B1 Antibody [H00008546-B01P] - Analysis of AP3B1 expression in human placenta.

Anti-AP3B1 antibody produced in mouse - SAB1409916 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-AP3B1: <B>Cat. No. SAB1409916</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~121.4 kDa using human placenta lysate.

Anti-AP3B1 (1-14) antibody produced in rabbit - SAB1105158 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of JURKAT cells was separated on SDS-PAGE, blotted with Anti-AP3B1 (1-14) (<B>Cat. No. SAB1105158</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250<BR/>2. Antibody dilution 1:250 + AP3B1 immunizing peptide (human, 1-14)

Anti-AP3B1 antibody produced in rabbit - HPA038737 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AP3B1: <B>Cat. No. HPA038737</B>: Immunohistochemical staining of human stomach shows moderate cytoplasmic positivity in glandular cells.

Anti-AP3B1 (N-terminal) antibody produced in rabbit - SAB2702075 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-AP3B1 (N-terminal): <B>Cat. No. SAB2702075</B>: Western blot analysis of AP3B1 in extracts from 30 μg of whole cell HepG2 7.5% SDS PAGE at a 1:1,000 dilution.

AP3B1-Antibody-monoclonal-M06 - AT1154a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B4
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
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