AP3B1
| Gene Symbol | AP3B1 |
|---|---|
| Entrez Gene | 8546 |
| Alt Symbol | ADTB3, ADTB3A, HPS, HPS2, PE |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 3, beta 1 subunit |
| Other Description | AP-3 complex beta-3A subunit|AP-3 complex subunit beta-1|adaptor protein complex AP-3 subunit beta-1|adaptor-related protein complex 3 subunit beta-1|beta-3A-adaptin|clathrin assembly protein complex 3 beta-1 large chain |
| Swissprots | Q9HD66 O00580 O00203 Q7Z393 E5RJ68 |
| Accessions | AAG01739 EAW95811 EAW95812 EAW95813 O00203 AK225908 AK291201 BAF83890 AK303300 BAG64374 AL708147 AY623424 AAT49048 BC020230 BC038444 AAH38444 BX538041 CAD97982 DA889915 DQ894915 ABM85841 EU176289 ABW03740 U81504 AAB61638 U91931 AAD03778 XM_005248618 XP_005248675 XM_005248619 XP_005248676 NM_001271769 NP_001258698 NM_003664 NP_003655 |
| Function | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Subcellular Location | Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:9151686, ECO:0000269|PubMed:9182526}. |
| Top Pathways | Lysosome |
AP-3β siRNA (h) - sc-41165 from Santa Cruz Biotechnology
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AP-3βshRNA Plasmid (h) - sc-41165-SH from Santa Cruz Biotechnology
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AP-3βshRNA (h) Lentiviral Particles - sc-41165-V from Santa Cruz Biotechnology
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AP3B1 RNAi - H00008546-R01 from Novus Biologicals
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MISSION® esiRNA - EHU010611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3292 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3292 from Sigma-Aldrich
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AP3B1 siRNA (Human) - CRH5617 from Cohesion Biosciences
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AP3B1 - MBS8238223 from MyBioSource
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shRNA set against Human AP3B1 (NM_003664.3) - SHH237878 from Creative biogene
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shRNA set against Human AP3B1(NM_003664.3) - SHG063559 from Creative biogene
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Human AP3B1 siRNA - orb266119 from Biorbyt
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AP3B1 shRNA Plasmid (Human) - CHH5617 from Cohesion Biosciences
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AP3B1 miRNA 3'UTR clone - MiUTR3H-05933 from Creative biogene
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