| Gene Symbol | YWHAQ |
|---|---|
| Entrez Gene | 10971 |
| Alt Symbol | 14-3-3, 1C5, HS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta |
| Other Description | 14-3-3 protein T-cell|14-3-3 protein tau|14-3-3 protein theta|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide |
| Swissprots | Q9UP48 D6W4Z5 P27348 Q5TZU8 Q567U5 |
| Accessions | AAX93143 AAY24326 CAJ42708 EAX00977 EAX00978 EAX00979 P27348 AA729400 AF070556 AAC28640 AK297624 BAG60000 AK302208 BAG63566 AK309462 AK316158 BAH14529 AM393330 CAL38208 AM393338 CAL38216 AM393358 CAL38236 AM393674 CAL38550 BC001197 BC050601 AAH50601 BC056867 AAH56867 BC093019 AAH93019 BT020014 AAV38817 HY044745 X56468 CAA39840 X57347 CAA40622 NM_006826 NP_006817 |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| Subcellular Location | Cytoplasm. Note=In neurons, axonally transported to the nerve terminals. |
| Tissue Specificity | Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269|PubMed:11080204}. |
| Top Pathways | Cell cycle, Pathogenic Escherichia coli infection, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway |
14-3-3 θ CRISPR/Cas9 KO Plasmid (h) - sc-401384 from Santa Cruz Biotechnology
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14-3-3 θ HDR Plasmid (h) - sc-401384-HDR from Santa Cruz Biotechnology
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14-3-3 θ Double Nickase Plasmid (h) - sc-401384-NIC from Santa Cruz Biotechnology
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14-3-3 θ Double Nickase Plasmid (h2) - sc-401384-NIC-2 from Santa Cruz Biotechnology
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14-3-3 θ CRISPR Activation Plasmid (h) - sc-401384-ACT from Santa Cruz Biotechnology
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14-3-3 θ CRISPR Activation Plasmid (h2) - sc-401384-ACT-2 from Santa Cruz Biotechnology
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14-3-3 θ Lentiviral Activation Particles (h) - sc-401384-LAC from Santa Cruz Biotechnology
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14-3-3 θ Lentiviral Activation Particles (h2) - sc-401384-LAC-2 from Santa Cruz Biotechnology
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14-3-3 θ siRNA (h) - sc-29586 from Santa Cruz Biotechnology
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14-3-3 θ shRNA Plasmid (h) - sc-29586-SH from Santa Cruz Biotechnology
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14-3-3 θ shRNA (h) Lentiviral Particles - sc-29586-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU105611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23034 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23034 from Sigma-Aldrich
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YWHAQ siRNA (Human) - CRH7490 from Cohesion Biosciences
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YWHAQ - MBS8207297 from MyBioSource
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shRNA set against Human YWHAQ (NM_006826.2) - SHH448712 from Creative biogene
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shRNA set against Human YWHAQ(NM_006826.2) - SHL132654 from Creative biogene
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YWHAQ shRNA Plasmid (Human) - CHH7490 from Cohesion Biosciences
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YWHAQ miRNA 3'UTR clone - MiUTR1H-11350 from Creative biogene
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