| Gene Symbol | CHST6 |
|---|---|
| Entrez Gene | 4166 |
| Alt Symbol | MCDC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
| Other Description | C-GlcNAc6ST|GST4-beta|N-acetylglucosamine 6-O-sulfotransferase 5|carbohydrate sulfotransferase 6|corneal N-acetylglucosamine 6-sulfotransferase|corneal N-acetylglucosamine-6-O-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta|glcNAc6ST-5|gn6st-5|hCGn6ST |
| Swissprots | Q9GZX3 D3DUK3 |
| Accessions | AAG26327 ADG26740 ADG26741 ADG26742 EAW95640 EAW95641 Q9GZX3 AF280086 AAG48244 BC036640 BC041645 BC074834 AAH74834 BC074883 AAH74883 XM_005255955 XP_005256012 XM_011523085 XP_011521387 NM_021615 NP_067628 |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. {ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea. {ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11181564, ECO:0000269|PubMed:11352640}. |
| Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |