| Gene Symbol |
CHST6
|
| Entrez Gene |
4166
|
| Alt Symbol |
MCDC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
|
| Other Description |
C-GlcNAc6ST|GST4-beta|N-acetylglucosamine 6-O-sulfotransferase 5|carbohydrate sulfotransferase 6|corneal N-acetylglucosamine 6-sulfotransferase|corneal N-acetylglucosamine-6-O-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta|glcNAc6ST-5|gn6st-5|hCGn6ST
|
| Swissprots |
Q9GZX3 D3DUK3
|
| Accessions |
AAG26327 ADG26740 ADG26741 ADG26742 EAW95640 EAW95641 Q9GZX3 AF280086 AAG48244 BC036640 BC041645 BC074834 AAH74834 BC074883 AAH74883 XM_005255955 XP_005256012 XM_011523085 XP_011521387 NM_021615 NP_067628
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. {ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea. {ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11181564, ECO:0000269|PubMed:11352640}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - keratan sulfate
|