Gene Symbol | CHST6 |
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Entrez Gene | 4166 |
Alt Symbol | MCDC1 |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Other Description | C-GlcNAc6ST|GST4-beta|N-acetylglucosamine 6-O-sulfotransferase 5|carbohydrate sulfotransferase 6|corneal N-acetylglucosamine 6-sulfotransferase|corneal N-acetylglucosamine-6-O-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta|glcNAc6ST-5|gn6st-5|hCGn6ST |
Swissprots | Q9GZX3 D3DUK3 |
Accessions | AAG26327 ADG26740 ADG26741 ADG26742 EAW95640 EAW95641 Q9GZX3 AF280086 AAG48244 BC036640 BC041645 BC074834 AAH74834 BC074883 AAH74883 XM_005255955 XP_005256012 XM_011523085 XP_011521387 NM_021615 NP_067628 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. {ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea. {ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11181564, ECO:0000269|PubMed:11352640}. |
Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |
Human CHST6 protein fragment - ab158867 from Abcam
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CHST6 Antibody Blocking Peptide - LS-E1604 from LifeSpan Bioscience
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CHST6 Antibody Blocking Peptide - LS-E17674 from LifeSpan Bioscience
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CHST6 Antibody Blocking Peptide - LS-E17675 from LifeSpan Bioscience
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Recombinant Human Carbohydrate Sulfotransferase 6/CHST6 Protein - H00004166-Q01 from Novus Biologicals
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CHST6-Antibody-C-term-Blocking-peptide - BP12350b from Abgent, a WuXi AppTec company
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Recombinant Human CHST6, CF - 5326-ST-020 from R&D Systems
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CHST6 Blocking Peptide - 33R-10046 from Fitzgerald
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CHST6 Blocking Peptide - 33R-7529 from Fitzgerald
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CHST6 Blocking Peptide - abx161356 from Abbexa
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CHST6 - H00004166-Q01 from Acris Antibodies
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CHST6 - H00004166-Q01-10 from Acris Antibodies
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CHST6 - H00004166-Q01-25 from Acris Antibodies
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CHST6 fusion protein - ag13653 from Proteintech Group
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CHST6 fusion protein - Ag24288 from Proteintech Group
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Recombinant Human CHST6, His-tagged - CHST6-738H from Creative Biomart
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CHST6 Blocking Peptide - CBP3855 from Cohesion Biosciences
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Recombinant Human Carbohydrate sulfotransferase 6(CHST6) - CSB-YP884425HU CSB-EP884425HU CSB-BP884425HU CSB-MP884425HU from Cusabio
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Recombinant Human CHST6 Protein, CF - 5326-ST from R&D Systems
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CHST6 (full length, N-term HIS tag) - TP760211 from Acris Antibodies
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Carbohydrate sulfotransferase 6 (CHST6), Recombinant Protein - MBS1423394 from MyBioSource
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CHST6 Peptide, Human - M34GP03155H from Creative Peptides
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CHST6 peptide - orb234730 from Biorbyt
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