Gene Symbol | CHST6 |
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Entrez Gene | 4166 |
Alt Symbol | MCDC1 |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Other Description | C-GlcNAc6ST|GST4-beta|N-acetylglucosamine 6-O-sulfotransferase 5|carbohydrate sulfotransferase 6|corneal N-acetylglucosamine 6-sulfotransferase|corneal N-acetylglucosamine-6-O-sulfotransferase|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta|glcNAc6ST-5|gn6st-5|hCGn6ST |
Swissprots | Q9GZX3 D3DUK3 |
Accessions | AAG26327 ADG26740 ADG26741 ADG26742 EAW95640 EAW95641 Q9GZX3 AF280086 AAG48244 BC036640 BC041645 BC074834 AAH74834 BC074883 AAH74883 XM_005255955 XP_005256012 XM_011523085 XP_011521387 NM_021615 NP_067628 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. {ECO:0000269|PubMed:11352640, ECO:0000269|PubMed:12218059}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea. {ECO:0000269|PubMed:11017086, ECO:0000269|PubMed:11181564, ECO:0000269|PubMed:11352640}. |
Top Pathways | Glycosaminoglycan biosynthesis - keratan sulfate |
CHST5/6 (H-59) - sc-367153 from Santa Cruz Biotechnology
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CHST5/6 (K-15) - sc-68027 from Santa Cruz Biotechnology
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CHST5/6 (N-15) - sc-68028 from Santa Cruz Biotechnology
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Anti-CHST6 antibody - ab201106 from Abcam
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Anti-CHST6 antibody - ab154332 from Abcam
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Anti-CHST6 antibody - ab84555 from Abcam
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Anti-CHST6 antibody - C-terminal - ab170753 from Abcam
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Anti-CHST6 Antibody (aa303-333, AP) - LS-C254827 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333, APC) - LS-C254828 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333, Biotin) - LS-C254829 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333, Azide-free, HRP) - LS-C254831 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333, PE) - LS-C254832 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333) - LS-C320383 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333, FITC) - LS-C254830 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa331-380) - LS-C119805 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa288-337) - LS-C111202 from LifeSpan Bioscience
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Anti-CHST6 Antibody (C-Terminus) - LS-C102325 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa303-333) - LS-C168764 from LifeSpan Bioscience
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Anti-CHST6 Antibody (aa202-395, clone 1D1) - LS-C336985 from LifeSpan Bioscience
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Carbohydrate Sulfotransferase 6/CHST6 Antibody - NBP1-57928 from Novus Biologicals
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Carbohydrate Sulfotransferase 6/CHST6 Antibody - NBP1-57927 from Novus Biologicals
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Carbohydrate Sulfotransferase 6/CHST6 Antibody - NBP1-32912 from Novus Biologicals
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Anti-CHST6 (ab1) antibody produced in rabbit - SAB2100428 from Sigma-Aldrich
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Anti-CHST6 (ab2) antibody produced in rabbit - SAB2100429 from Sigma-Aldrich
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Anti-CHST6, C-Terminal antibody produced in rabbit - SAB4501842 from Sigma-Aldrich
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