ZAK

Gene Symbol ZAK
Entrez Gene 51776
Alt Symbol AZK, MLK7, MLT, MLTK, MRK, mlklak, pk
Species Human
Gene Type protein-coding
Description sterile alpha motif and leucine zipper containing kinase AZK
Other Description HCCS-4|MLK-like mitogen-activated protein triple kinase|human cervical cancer suppressor gene 4 protein|mitogen-activated protein kinase kinase kinase MLT|mixed lineage kinase 7|mixed lineage kinase with a leucine zipper and a sterile alpha motif|mixed lineage kinase-related kinase MRK-beta
Swissprots Q580W8 Q59GY5 B3KPG2 Q9HCC5 Q9NYL2 Q9NYE9 Q86YW8 Q9HCC4 Q9HDD2 Q53SX1
Accessions AAX82002 AAX93067 CAH05528 EAX11164 EAX11165 EAX11166 Q9NYL2 AA258354 AB030034 BAB12040 AB041883 BAJ05400 AB049733 BAB16444 AB049734 BAB16445 AB208974 BAD92211 AF238255 AAF63490 AF251441 AAF65822 AF325454 AAK11615 AF465843 AAO33376 AF480461 AAL85891 AF480462 AAL85892 AI799498 AK056310 BAG51674 AK095825 AK096877 AK291825 BAF84514 AK298634 BAG60809 AL833180 BC001401 AAH01401 BF055268 CB955745 DA993056 XM_005246640 XP_005246697 NM_016653 NP_057737 NM_133646 NP_598407
Function Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15684425}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15684425}. Nucleus {ECO:0000269|PubMed:15684425}. Note=Translocates to the nucleus upon ultraviolet B irradiation.
Tissue Specificity Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11836244}.
Top Pathways Tight junction, MAPK signaling pathway

MLTK (A-2) - sc-390924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MLTK (A-2): sc-390924. Western blot analysis of MLTK expression in HeLa (A), NIH/3T3 (B) and Hep G2 (C) whole cell lysates.

MLTK (H-300) - sc-134970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MLTK (H-300): sc-134970. Western blot analysis of MLTK expression in HeLa whole cell lysate.

MLTK (K-17) - sc-67684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MLTK (K-17): sc-67684. Western blot analysis of MLTK expression in NIH/3T3 whole cell lysate.

MLTK (D-18) - sc-67682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MLTK (D-18): sc-67682. Western blot analysis of MLTK expression in NIH/3T3 whole cell lysate.

Anti-ZAK antibody - ab65249 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65249 at 1/500 dilution staining ZAK in HepG2 cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-ZAK antibody - ab99933 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ZAK antibody (ab99933) at 1/500 dilution + HeLa Cell Lysate

Anti-ZAK antibody - ab190164 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin labeling ZAK with ab190164 at 5 µg/ml.

Anti-ZAK antibody - ab57318 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57318 ZAK antibody at 1ug/ml.

Anti-ZAK antibody [EPR10016(B)] - ab166895 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10016(B)
All lanes : Anti-ZAK antibody [EPR10016(B)] (ab166895) at 1/1000 dilutionLane 1 : Fetal liver lysateLane 2 : HeLa lysateLane 3 : HepG2 lysateLane 4 : Jurkat lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ZAK / MLTK Antibody IHC-plus™ - LS-B9394 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ZAK antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ZAK / MLTK Antibody (Internal, Biotin) - LS-C279622 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (Internal, AP) - LS-C279621 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (Internal, APC) - LS-C279623 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (Internal, FITC) - LS-C279624 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (Internal, Azide-free, HRP) - LS-C279625 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (Internal, PE) - LS-C279628 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (aa700-750) - LS-C288750 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK / MLTK Antibody (clone 3G5) - LS-C105146 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G5
ZAK monoclonal antibody (M03), clone 3G5. Western blot of ZAK expression in human stomach.

Anti-ZAK / MLTK Antibody (Internal) - LS-C327923 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZAK Antibody (aa1-456, Azide-free) - LS-C330528 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-ZAK / MLTK Antibody (aa701-750) - LS-C119288 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using MLTK Antibody. The picture on the right is treated with the synthesized peptide.

Anti-ZAK / MLTK Antibody (aa271-300) - LS-C101159 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-ZAK / MLTK Antibody (aa131-180) - LS-C199741 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using ZAK Antibody. The lane on the right was incubated with synthetic peptide.

Anti-ZAK / MLTK Antibody (aa750-800) - LS-C288751 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ZAK by Immunohistochemistry. Sample: FFPE section of human skin carcinoma. Antibody: Affinity purified rabbit anti-ZAK used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-ZAK / MLTK Antibody (aa750-800) - LS-C286802 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ZAK by Immunohistochemistry. Sample: FFPE section of human skin squamous cell carcinoma. Antibody: Affinity purified rabbit anti-ZAK used at a dilution of 1:250.
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