ZAK

Gene Symbol ZAK
Entrez Gene 51776
Alt Symbol AZK, MLK7, MLT, MLTK, MRK, mlklak, pk
Species Human
Gene Type protein-coding
Description sterile alpha motif and leucine zipper containing kinase AZK
Other Description HCCS-4|MLK-like mitogen-activated protein triple kinase|human cervical cancer suppressor gene 4 protein|mitogen-activated protein kinase kinase kinase MLT|mixed lineage kinase 7|mixed lineage kinase with a leucine zipper and a sterile alpha motif|mixed lineage kinase-related kinase MRK-beta
Swissprots Q580W8 Q59GY5 B3KPG2 Q9HCC5 Q9NYL2 Q9NYE9 Q86YW8 Q9HCC4 Q9HDD2 Q53SX1
Accessions AAX82002 AAX93067 CAH05528 EAX11164 EAX11165 EAX11166 Q9NYL2 AA258354 AB030034 BAB12040 AB041883 BAJ05400 AB049733 BAB16444 AB049734 BAB16445 AB208974 BAD92211 AF238255 AAF63490 AF251441 AAF65822 AF325454 AAK11615 AF465843 AAO33376 AF480461 AAL85891 AF480462 AAL85892 AI799498 AK056310 BAG51674 AK095825 AK096877 AK291825 BAF84514 AK298634 BAG60809 AL833180 BC001401 AAH01401 BF055268 CB955745 DA993056 XM_005246640 XP_005246697 NM_016653 NP_057737 NM_133646 NP_598407
Function Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15684425}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15684425}. Nucleus {ECO:0000269|PubMed:15684425}. Note=Translocates to the nucleus upon ultraviolet B irradiation.
Tissue Specificity Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11836244}.
Top Pathways Tight junction, MAPK signaling pathway

MLTK CRISPR/Cas9 KO Plasmid (h) - sc-405472 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK HDR Plasmid (h) - sc-405472-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK Double Nickase Plasmid (h) - sc-405472-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK Double Nickase Plasmid (h2) - sc-405472-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK CRISPR Activation Plasmid (h) - sc-405472-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK CRISPR Activation Plasmid (h2) - sc-405472-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK Lentiviral Activation Particles (h) - sc-405472-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK Lentiviral Activation Particles (h2) - sc-405472-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLTK siRNA (h) - sc-62625 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLTK shRNA Plasmid (h) - sc-62625-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLTK shRNA (h) Lentiviral Particles - sc-62625-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZAK RNAi - H00051776-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ZAK RNAi - H00051776-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU058171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2485 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2487 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2486 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN23041 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23041 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ZAK siRNA (Human) - CRH9945 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZAK - MBS8240248 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ZAK (NM_016653.2) - SHH448776 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ZAK(NM_133646.2) - SHH224268 from Creative biogene

Category siRNA
Species Reactivities Human

Human ZAK siRNA - orb270447 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZAK shRNA Plasmid (Human) - CHH9945 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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