ZAK

Gene Symbol	ZAK
Entrez Gene	51776
Alt Symbol	AZK, MLK7, MLT, MLTK, MRK, mlklak, pk
Species	Human
Gene Type	protein-coding
Description	sterile alpha motif and leucine zipper containing kinase AZK
Other Description	HCCS-4|MLK-like mitogen-activated protein triple kinase|human cervical cancer suppressor gene 4 protein|mitogen-activated protein kinase kinase kinase MLT|mixed lineage kinase 7|mixed lineage kinase with a leucine zipper and a sterile alpha motif|mixed lineage kinase-related kinase MRK-beta
Swissprots	Q580W8 Q59GY5 B3KPG2 Q9HCC5 Q9NYL2 Q9NYE9 Q86YW8 Q9HCC4 Q9HDD2 Q53SX1
Accessions	AAX82002 AAX93067 CAH05528 EAX11164 EAX11165 EAX11166 Q9NYL2 AA258354 AB030034 BAB12040 AB041883 BAJ05400 AB049733 BAB16444 AB049734 BAB16445 AB208974 BAD92211 AF238255 AAF63490 AF251441 AAF65822 AF325454 AAK11615 AF465843 AAO33376 AF480461 AAL85891 AF480462 AAL85892 AI799498 AK056310 BAG51674 AK095825 AK096877 AK291825 BAF84514 AK298634 BAG60809 AL833180 BC001401 AAH01401 BF055268 CB955745 DA993056 XM_005246640 XP_005246697 NM_016653 NP_057737 NM_133646 NP_598407
Function	Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro- apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15684425}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15684425}. Nucleus {ECO:0000269|PubMed:15684425}. Note=Translocates to the nucleus upon ultraviolet B irradiation.
Tissue Specificity	Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed. {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11836244}.
Top Pathways	Tight junction, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ZAK-Over-expression-Lysate - LY10617a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ZAK overexpression lysate - LY413852 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ZAK overexpression lysate - LY429511 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ZAK 293 Cell Lysate - 404761 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ZAK Overexpression Lysate (Native) - NBL1-17956 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ZAK Overexpression Lysate (Native) - NBP2-07004 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ZAK Over-expression Lysate Product - GWB-20AE0D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ZAK Overexpression Lysate (Native) - NBP2-09880 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human ZAK Knockdown Stable Cell Line - CSC-DC017653 from Creative biogene Category Cell Line Species Human

Human ZAK Knockout Cell Line-HeLa - CSC-RT1507 from Creative biogene Category Cell Line Species Human

ZAK KO Cell Lysate-HeLa - CLKO-1355 from Creative biogene Category Cell Lysate

Search more