| Gene Symbol |
TAX1BP3
|
| Entrez Gene |
30851
|
| Alt Symbol |
TIP-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Tax1 (human T-cell leukemia virus type I) binding protein 3
|
| Other Description |
Tax interaction protein 1|glutaminase-interacting protein 3|tax-interacting protein 1|tax1-binding protein 3
|
| Swissprots |
D3DTJ6 O14907 Q7LCQ4 B2RD53
|
| Accessions |
AAF43104 EAW90491 EAW90492 EAW90493 O14907 AF028823 AAB84248 AF234997 AAG44368 AF277318 AAK69111 AK001327 AK315408 BAG37800 BC023980 AAH23980 BM973411 CB129195 HQ447711 ADQ32196 U90913 NM_001204698 NP_001191627 NM_014604 NP_055419
|
| Function |
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024, ECO:0000269|PubMed:21139582}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.
|
| Tissue Specificity |
Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:16855024}.
|
![Western Blot: TAX1BP3 Overexpression Lysate (Adult Normal) [NBL1-16717] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TAX1BP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3008_TAX1BP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16717-img0002.jpg)