| Gene Symbol |
ITGA4
|
| Entrez Gene |
3676
|
| Alt Symbol |
CD49D, IA4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
|
| Other Description |
269C wild type|CD49 antigen-like family member D|VLA-4 subunit alpha|antigen CD49D, alpha-4 subunit of VLA-4 receptor|integrin alpha 4|integrin alpha-4|integrin alpha-4 subunit|integrin alpha-IV|very late activation protein 4 receptor, alpha 4 subunit
|
| Swissprots |
D3DPG4 Q7Z4L6 P13612
|
| Accessions |
AAB25486 AGZ05039 AGZ05040 AGZ05041 AGZ05042 AGZ05043 AGZ05044 AGZ05045 AGZ05046 AGZ05047 AGZ05048 AGZ05049 AGZ05050 AGZ05051 AGZ05052 AGZ05053 AGZ05054 AGZ05055 AGZ05056 AGZ05057 AGZ05058 AGZ05059 AGZ05060 AGZ05061 AGZ05062 AGZ05063 AGZ05064 AGZ05065 AGZ05066 AGZ05067 AGZ05068 AGZ05069 AGZ05070 AGZ05071 AGZ05072 AGZ05073 AGZ05074 AGZ05075 AGZ05076 AGZ05077 AGZ05078 AGZ05079 AGZ05080 AGZ05081 AGZ05082 AGZ05083 AGZ05084 AGZ05085 AGZ05086 AGZ05087 AGZ05088 AGZ05089 AGZ05090 AGZ05091 AGZ05092 AGZ05093 AGZ05094 AGZ05095 AGZ05096 AGZ05097 AGZ05098 AGZ05099 AGZ05100 AGZ05101 AGZ05102 AGZ05103 AGZ05104 AGZ05105 AGZ05106 AGZ05107 AGZ05108 AGZ05109 AGZ05110 AGZ05111 AGZ05112 AGZ05113 AGZ05114 AGZ05115 AGZ05116 AGZ05117 AGZ05118 AGZ05119 AGZ05120 AGZ05121 AGZ05122 AGZ05123 EAX10985 EAX10986 EAX10987 P13612 AB208885 BAD92122 AJ504733 CAD43289 AJ508356 CAD48165 AJ510246 CAD53326 AJ510247 CAD53327 AJ510248 CAD53328 AJ510249 CAD53329 AK303220 BAG64307 AK303478 BAG64514 AK310610 AK311738 BC016671 AAH16671 BC055419 AAH55419 BC080190 AAH80190 BC146277 AAI46278 BC156712 AAI56713 L12002 AAB59613 X16983 CAA34852 NM_000885 NP_000876
|
| Function |
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. {ECO:0000269|PubMed:19064666}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Hypertrophic cardiomyopathy (HCM), PI3K-Akt signaling pathway, Leishmaniasis, Intestinal immune network for IgA production, Dilated cardiomyopathy
|
![Western Blot: Integrin alpha 4 Overexpression Lysate (Adult Normal) [NBL1-12064] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Integrin alpha 4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3635_Integrin%2520alpha%25204%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12064-img0002.jpg)