ITGA4

Gene Symbol	ITGA4
Entrez Gene	3676
Alt Symbol	CD49D, IA4
Species	Human
Gene Type	protein-coding
Description	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Other Description	269C wild type|CD49 antigen-like family member D|VLA-4 subunit alpha|antigen CD49D, alpha-4 subunit of VLA-4 receptor|integrin alpha 4|integrin alpha-4|integrin alpha-4 subunit|integrin alpha-IV|very late activation protein 4 receptor, alpha 4 subunit
Swissprots	D3DPG4 Q7Z4L6 P13612
Accessions	AAB25486 AGZ05039 AGZ05040 AGZ05041 AGZ05042 AGZ05043 AGZ05044 AGZ05045 AGZ05046 AGZ05047 AGZ05048 AGZ05049 AGZ05050 AGZ05051 AGZ05052 AGZ05053 AGZ05054 AGZ05055 AGZ05056 AGZ05057 AGZ05058 AGZ05059 AGZ05060 AGZ05061 AGZ05062 AGZ05063 AGZ05064 AGZ05065 AGZ05066 AGZ05067 AGZ05068 AGZ05069 AGZ05070 AGZ05071 AGZ05072 AGZ05073 AGZ05074 AGZ05075 AGZ05076 AGZ05077 AGZ05078 AGZ05079 AGZ05080 AGZ05081 AGZ05082 AGZ05083 AGZ05084 AGZ05085 AGZ05086 AGZ05087 AGZ05088 AGZ05089 AGZ05090 AGZ05091 AGZ05092 AGZ05093 AGZ05094 AGZ05095 AGZ05096 AGZ05097 AGZ05098 AGZ05099 AGZ05100 AGZ05101 AGZ05102 AGZ05103 AGZ05104 AGZ05105 AGZ05106 AGZ05107 AGZ05108 AGZ05109 AGZ05110 AGZ05111 AGZ05112 AGZ05113 AGZ05114 AGZ05115 AGZ05116 AGZ05117 AGZ05118 AGZ05119 AGZ05120 AGZ05121 AGZ05122 AGZ05123 EAX10985 EAX10986 EAX10987 P13612 AB208885 BAD92122 AJ504733 CAD43289 AJ508356 CAD48165 AJ510246 CAD53326 AJ510247 CAD53327 AJ510248 CAD53328 AJ510249 CAD53329 AK303220 BAG64307 AK303478 BAG64514 AK310610 AK311738 BC016671 AAH16671 BC055419 AAH55419 BC080190 AAH80190 BC146277 AAI46278 BC156712 AAI56713 L12002 AAB59613 X16983 CAA34852 NM_000885 NP_000876
Function	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. {ECO:0000269|PubMed:19064666}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Top Pathways	Hypertrophic cardiomyopathy (HCM), PI3K-Akt signaling pathway, Leishmaniasis, Intestinal immune network for IgA production, Dilated cardiomyopathy

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Integrin α4 (D2E1) XP ® Rabbit mAb - 8440 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D2E1

Integrin α4 Antibody - 4600 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Integrin α4 (A-7) - sc-365209 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Integrin α4 (C-2) - sc-365569 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Integrin α4 (H-210) - sc-14008 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Integrin α4 (B-2) - sc-376334 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Integrin α4 (C-20) - sc-6589 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Integrin α4 (N-19) - sc-6590 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Integrin α4 (9F10) - sc-23933 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Integrin α4 (PS/2) - sc-52593 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rat Clonality Monoclonal

Integrin α4/β7 (DATK32) - sc-23920 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rat Clonality Monoclonal

p-Integrin α4 (Ser 988) - sc-23943 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-CD49d antibody - ab202969 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Integrin alpha 4 (phospho S1027) antibody [EPR2343] - ab75760 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2343

Anti-Integrin alpha 4 antibody - ab76975 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Integrin alpha 4 antibody [44H6] - ab220 from Abcam Prices $379.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 44H6

Anti-Integrin alpha 4 antibody [44H6] (Biotin) - ab30492 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 44H6

Anti-Integrin alpha 4 antibody [44H6] (FITC) - ab221 from Abcam Prices $188.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 44H6

Anti-Integrin alpha 4 antibody [5C4] - ab128181 from Abcam Prices $384.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5C4

Anti-Integrin alpha 4 antibody [ALC1/1] (Allophycocyanin) - ab91054 from Abcam Prices $370.00 Sizes 50 tests Host Mouse Clonality Monoclonal Clone ALC1/1

Anti-Integrin alpha 4 antibody [ALC1/1] (CF405M) - ab115904 from Abcam Prices $376.00 Sizes 50 tests Host Mouse Clonality Monoclonal Clone ALC1/1

Anti-Integrin alpha 4 antibody [ALC1/1] (FITC) - ab91055 from Abcam Prices $376.00 Sizes 50 tests Host Mouse Clonality Monoclonal Clone ALC1/1

Anti-Integrin alpha 4 antibody [ALC1/1] (PerCP) - ab91056 from Abcam Prices $370.00 Sizes 50 tests Host Mouse Clonality Monoclonal Clone ALC1/1

Anti-Integrin alpha 4 antibody [ALC1/1] (Phycoerythrin) - ab91051 from Abcam Prices $370.00 Sizes 50 tests Host Mouse Clonality Monoclonal Clone ALC1/1

Anti-Integrin alpha 4 antibody [EPR1355Y] - ab81280 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1355Y

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