| Gene Symbol |
HIST3H3
|
| Entrez Gene |
8290
|
| Alt Symbol |
H3.4, H3/g, H3FT, H3t
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 3, H3
|
| Other Description |
H3 histone family, member T|H3/t|histone 3, H3|histone H3.1t
|
| Swissprots |
Q16695 Q6FGU4 B2R5K3
|
| Accessions |
AAN39284 CAA90020 EAW69877 Q16695 AK312217 BAG35150 BC069079 AAH69079 BC101837 AAI01838 BC101839 AAI01840 CR542013 CAG46810 DQ587912 NM_003493 NP_003484
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Tissue Specificity |
Expressed in testicular cells.
|
| Top Pathways |
Systemic lupus erythematosus, Alcoholism, Transcriptional misregulation in cancer
|
![Western Blot: HIST3H3 Overexpression Lysate (Adult Normal) [NBP2-08000] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HIST3H3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15523_HIST3H3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08000-img0001.jpg)