Gene Symbol | HIST3H3 |
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Entrez Gene | 8290 |
Alt Symbol | H3.4, H3/g, H3FT, H3t |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 3, H3 |
Other Description | H3 histone family, member T|H3/t|histone 3, H3|histone H3.1t |
Swissprots | Q16695 Q6FGU4 B2R5K3 |
Accessions | AAN39284 CAA90020 EAW69877 Q16695 AK312217 BAG35150 BC069079 AAH69079 BC101837 AAI01838 BC101839 AAI01840 CR542013 CAG46810 DQ587912 NM_003493 NP_003484 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Tissue Specificity | Expressed in testicular cells. |
Top Pathways | Systemic lupus erythematosus, Alcoholism, Transcriptional misregulation in cancer |
Histone cluster 3 H3 CRISPR/Cas9 KO Plasmid (h) - sc-411135 from Santa Cruz Biotechnology
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Histone cluster 3 H3 HDR Plasmid (h) - sc-411135-HDR from Santa Cruz Biotechnology
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Histone cluster 3 H3 Double Nickase Plasmid (h) - sc-411135-NIC from Santa Cruz Biotechnology
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Histone cluster 3 H3 Double Nickase Plasmid (h2) - sc-411135-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 3 H3 CRISPR Activation Plasmid (h) - sc-411135-ACT from Santa Cruz Biotechnology
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Histone cluster 3 H3 CRISPR Activation Plasmid (h2) - sc-411135-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 3 H3 Lentiviral Activation Particles (h) - sc-411135-LAC from Santa Cruz Biotechnology
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Histone cluster 3 H3 Lentiviral Activation Particles (h2) - sc-411135-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 3 H3 siRNA (h) - sc-105519 from Santa Cruz Biotechnology
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Histone cluster 3 H3 shRNA Plasmid (h) - sc-105519-SH from Santa Cruz Biotechnology
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Histone cluster 3 H3 shRNA (h) Lentiviral Particles - sc-105519-V from Santa Cruz Biotechnology
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HIST3H3 RNAi - H00008290-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10119 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10119 from Sigma-Aldrich
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HIST3H3 siRNA (Human) - CRH5425 from Cohesion Biosciences
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HIST3H3 - MBS8200975 from MyBioSource
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shRNA set against Human HIST3H3 (NM_003493.2) - SHH313021 from Creative biogene
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Human HIST3H3 siRNA - orb265927 from Biorbyt
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HIST3H3 shRNA Plasmid (Human) - CHH5425 from Cohesion Biosciences
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HIST3H3 miRNA 3'UTR clone - MiUTR1H-04573 from Creative biogene
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