ANPEP

Gene Symbol	ANPEP
Entrez Gene	290
Alt Symbol	APN, CD13, GP150, LAP1, P150, PEPN
Species	Human
Gene Type	protein-coding
Description	alanyl (membrane) aminopeptidase
Other Description	AP-M|AP-N|alanyl aminopeptidase|aminopeptidase M|aminopeptidase N|hAPN|microsomal aminopeptidase|myeloid plasma membrane glycoprotein CD13
Swissprots	P15144 Q16728 Q8IUK3 Q8IVH3 Q9UCE0 Q6GT90
Accessions	AAA83399 AAQ09003 CAD19098 CAD19802 CAD19822 CAD20931 CDM22281 EAX02067 EAX02068 P15144 AB209918 BAD93155 AK298134 BAG60413 AK298242 BAG60508 AK298339 BAG60587 AK300946 BAG62575 BC058928 AAH58928 BQ879097 M22324 AAA51719 X13276 CAA31640 XM_005254892 XP_005254949 XM_011521473 XP_011519775 XM_011521474 XP_011519776 NM_001150 NP_001141
Function	Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. {ECO:00
Subcellular Location	Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol {ECO:0000305}. Note=A soluble form has also been detected.
Tissue Specificity	Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Top Pathways	Hematopoietic cell lineage, Glutathione metabolism, Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse ANPEP / CD13 ELISA Kit (Sandwich ELISA) - LS-F2897 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 312-20000 pg/ml

Human ANPEP / CD13 ELISA Kit (Sandwich ELISA) - LS-F2892 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 312 pg/ml Range 312-20000 pg/ml

Human ANPEP / CD13 ELISA Kit (Sandwich ELISA) - LS-F6380 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.57 ng/ml Range 312-20000 pg/ml

Rat ANPEP / CD13 ELISA Kit (Sandwich ELISA) - LS-F10805 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 312-20000 pg/ml

Mouse ANPEP / CD13 ELISA Kit (Sandwich ELISA) - LS-F10806 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 312-20000 pg/ml

Human Aminopeptidase N/CD13 DuoSet ELISA - DY3815 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 0.312 - 20 ng/mL

Human CD13 ELISA Kit - abx056061 from Abbexa Category ELISA Kit

Alanyl (membrane) aminopeptidase (ANPEP), Human, ELISA Kit - E01A1536 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Alanyl (membrane) aminopeptidase, Human, ELISA Kit - CSB-EL001827HU from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Aminopeptidase N, ANPEP, Human, ELISA Kit - E9154h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t

ANPEP (Human) IP-WB Antibody Pair - H00000290-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human Aminopeptidase N ELISA - ELH-ANPEP from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Anserine APN ELISA Kit - AA0132 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

alanyl (membrane) aminopeptidase, ELISA Kit - MBS936191 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ANPEP is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

alanyl (membrane) aminopeptidase (ANPEP), ELISA Kit - MBS7214750 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Aminopeptidase N, ELISA Kit - MBS281423 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Angiotensin 2 Receptor 1 Antibody, ELISA Kit - MBS070162 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Angiotensin 2 Receptor 1 Antibody, ELISA Kit - MBS019009 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Angiotensin 2 Receptor 1 Antibody, ELISA Kit - MBS010325 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Angiotensin 2 Receptor 1 Antibody, ELISA Kit - MBS088663 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Angiotensin 2 Receptor 1 Antibody, ELISA Kit - MBS014427 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Angiotensin 2 Receptor 1 Antibody, ELISA Kit - MBS040539 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Alanine Aminopeptidase (AAP) - SEB065Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.57ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Alanine Aminopeptidase (AAP) - SEB065Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

Angiotensin 1 Receptor Antibody, ELISA Kit - MBS012544 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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