| Gene Symbol |
ANPEP
|
| Entrez Gene |
290
|
| Alt Symbol |
APN, CD13, GP150, LAP1, P150, PEPN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alanyl (membrane) aminopeptidase
|
| Other Description |
AP-M|AP-N|alanyl aminopeptidase|aminopeptidase M|aminopeptidase N|hAPN|microsomal aminopeptidase|myeloid plasma membrane glycoprotein CD13
|
| Swissprots |
P15144 Q16728 Q8IUK3 Q8IVH3 Q9UCE0 Q6GT90
|
| Accessions |
AAA83399 AAQ09003 CAD19098 CAD19802 CAD19822 CAD20931 CDM22281 EAX02067 EAX02068 P15144 AB209918 BAD93155 AK298134 BAG60413 AK298242 BAG60508 AK298339 BAG60587 AK300946 BAG62575 BC058928 AAH58928 BQ879097 M22324 AAA51719 X13276 CAA31640 XM_005254892 XP_005254949 XM_011521473 XP_011519775 XM_011521474 XP_011519776 NM_001150 NP_001141
|
| Function |
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. {ECO:00
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol {ECO:0000305}. Note=A soluble form has also been detected.
|
| Tissue Specificity |
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
|
| Top Pathways |
Hematopoietic cell lineage, Glutathione metabolism, Renin-angiotensin system
|
