ANPEP

Gene Symbol	ANPEP
Entrez Gene	290
Alt Symbol	APN, CD13, GP150, LAP1, P150, PEPN
Species	Human
Gene Type	protein-coding
Description	alanyl (membrane) aminopeptidase
Other Description	AP-M|AP-N|alanyl aminopeptidase|aminopeptidase M|aminopeptidase N|hAPN|microsomal aminopeptidase|myeloid plasma membrane glycoprotein CD13
Swissprots	P15144 Q16728 Q8IUK3 Q8IVH3 Q9UCE0 Q6GT90
Accessions	AAA83399 AAQ09003 CAD19098 CAD19802 CAD19822 CAD20931 CDM22281 EAX02067 EAX02068 P15144 AB209918 BAD93155 AK298134 BAG60413 AK298242 BAG60508 AK298339 BAG60587 AK300946 BAG62575 BC058928 AAH58928 BQ879097 M22324 AAA51719 X13276 CAA31640 XM_005254892 XP_005254949 XM_011521473 XP_011519775 XM_011521474 XP_011519776 NM_001150 NP_001141
Function	Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection. {ECO:00
Subcellular Location	Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol {ECO:0000305}. Note=A soluble form has also been detected.
Tissue Specificity	Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Top Pathways	Hematopoietic cell lineage, Glutathione metabolism, Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD13 full length protein - ab134454 from Abcam Category Protein Prices $755.00 Sizes 50 µl Species Human

CD13 peptide - ab105987 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

CD13 peptide - ab105993 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD13 protein fragment - ab126023 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

ANPEP / CD13 Antibody Blocking Peptide - LS-E22326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ANPEP / CD13 Antibody Blocking Peptide - LS-E9090 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Aminopeptidase N/CD13 Partial Recombinant Protein - H00000290-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Aminopeptidase N/CD13 Protein - H00000290-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Aminopeptidase N/CD13 Protein - P4918 from Novus Biologicals Category Protein Prices $1,049.00 Sizes 10 µg Species Human

Aminopeptidase N/CD13 Recombinant Protein - H00000290-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

ANPEP-Antibody-Center-Blocking-Peptide - BP7601c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Aminopeptidase N/CD13, CF - 3815-ZN-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Lys69-Lys967, with a C-terminal 10-His tag

Human ANPEP His tag protein - orb82857 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

ANPEP Blocking Peptide - 33R-9557 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CD13 Blocking Peptide - abx062241 from Abbexa Category Peptide Species Human, Mouse

CD13 - H00000290-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD13 - H00000290-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CD13 - H00000290-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD13 - H00000290-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD13 - P4918 from Acris Antibodies Category Protein Prices $670.00 Sizes 10 µg Species Human

CD13 Control Peptide - AP09886CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

ANPEP fusion protein - ag5976 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ANPEP fusion protein - ag6064 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ANPEP, His tagged - ANPEP-249H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human ANPEP, His-tagged - ANPEP-694H from Creative Biomart Category Protein Source NSO cells Species Human

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