| Gene Symbol |
TNIK
|
| Entrez Gene |
23043
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TRAF2 and NCK interacting kinase
|
| Other Description |
TRAF2 and NCK-interacting protein kinase
|
| Swissprots |
Q9UKE4 D3DNQ6 Q9UKE0 A8K4U1 Q9UKD8 A7E2A3 Q9UKE5 Q8WUY7 Q9UKD9 Q9UKE2 Q9UKE3 Q9UKE1 O60298
|
| Accessions |
EAW78483 EAW78484 EAW78485 EAW78486 EAW78487 EAW78488 EAW78489 EAW78490 EAW78491 EAW78492 EAW78493 EAW78494 Q9UKE5 AB011123 BAA25477 AB017115 BAA76518 AF172264 AAF03782 AF172265 AAF03783 AF172266 AAF03784 AF172267 AAF03785 AF172268 AAF03786 AF172269 AAF03787 AF172270 AAF03788 AF172271 AAF03789 AK026470 AK291056 BAF83745 AW296249 BC018093 BC019081 AAH19081 BC055427 AAH55427 BC150256 AAI50257 NM_001161560 NP_001155032 NM_001161561 NP_001155033 NM_001161562 NP_001155034 NM_001161563 NP_001155035 NM_001161564 NP_001155036 NM_001161565 NP_001155037 NM_001161566 NP_001155038 NM_015028 NP_055843 NR_027767
|
| Function |
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
|
| Tissue Specificity |
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:19816403}.
|