TNIK

Gene Symbol TNIK
Entrez Gene 23043
Alt Symbol -
Species Human
Gene Type protein-coding
Description TRAF2 and NCK interacting kinase
Other Description TRAF2 and NCK-interacting protein kinase
Swissprots Q9UKE4 D3DNQ6 Q9UKE0 A8K4U1 Q9UKD8 A7E2A3 Q9UKE5 Q8WUY7 Q9UKD9 Q9UKE2 Q9UKE3 Q9UKE1 O60298
Accessions EAW78483 EAW78484 EAW78485 EAW78486 EAW78487 EAW78488 EAW78489 EAW78490 EAW78491 EAW78492 EAW78493 EAW78494 Q9UKE5 AB011123 BAA25477 AB017115 BAA76518 AF172264 AAF03782 AF172265 AAF03783 AF172266 AAF03784 AF172267 AAF03785 AF172268 AAF03786 AF172269 AAF03787 AF172270 AAF03788 AF172271 AAF03789 AK026470 AK291056 BAF83745 AW296249 BC018093 BC019081 AAH19081 BC055427 AAH55427 BC150256 AAI50257 NM_001161560 NP_001155032 NM_001161561 NP_001155033 NM_001161562 NP_001155034 NM_001161563 NP_001155035 NM_001161564 NP_001155036 NM_001161565 NP_001155037 NM_001161566 NP_001155038 NM_015028 NP_055843 NR_027767
Function Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388}.
Subcellular Location Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Tissue Specificity Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:19816403}.

TNIK CRISPR/Cas9 KO Plasmid (h) - sc-401523 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK HDR Plasmid (h) - sc-401523-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK Double Nickase Plasmid (h) - sc-401523-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK Double Nickase Plasmid (h2) - sc-401523-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK CRISPR Activation Plasmid (h) - sc-401523-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK CRISPR Activation Plasmid (h2) - sc-401523-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK Lentiviral Activation Particles (h) - sc-401523-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK Lentiviral Activation Particles (h2) - sc-401523-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TNIK siRNA (h) - sc-78453 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TNIK shRNA Plasmid (h) - sc-78453-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TNIK shRNA (h) Lentiviral Particles - sc-78453-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TNIK RNAi - H00023043-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: TNIK RNAi [H00023043-R01V] - Analysis of TNIK over-expressed 293 cell line, cotransfected with TNIK Validated Chimera RNAi or non-transfected control. Blot probed with H00023043-M04. GAPDH (36.1 kDa) used as loading control.

TNIK RNAi - H00023043-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU089121 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK2300 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2302 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2301 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN21771 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21771 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TNIK siRNA (Human) - CRH7956 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNIK - MBS8226865 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TNIK (NM_015028.2) - SHH432216 from Creative biogene

Category siRNA
Species Reactivities Human

Human TNIK siRNA - orb268458 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TNIK shRNA Plasmid (Human) - CHH7956 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TNIK miRNA 3'UTR clone - MiUTR3H-10953 from Creative biogene

Species Reactivities Human
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