TNIK

Gene Symbol TNIK
Entrez Gene 23043
Alt Symbol -
Species Human
Gene Type protein-coding
Description TRAF2 and NCK interacting kinase
Other Description TRAF2 and NCK-interacting protein kinase
Swissprots Q9UKE4 D3DNQ6 Q9UKE0 A8K4U1 Q9UKD8 A7E2A3 Q9UKE5 Q8WUY7 Q9UKD9 Q9UKE2 Q9UKE3 Q9UKE1 O60298
Accessions EAW78483 EAW78484 EAW78485 EAW78486 EAW78487 EAW78488 EAW78489 EAW78490 EAW78491 EAW78492 EAW78493 EAW78494 Q9UKE5 AB011123 BAA25477 AB017115 BAA76518 AF172264 AAF03782 AF172265 AAF03783 AF172266 AAF03784 AF172267 AAF03785 AF172268 AAF03786 AF172269 AAF03787 AF172270 AAF03788 AF172271 AAF03789 AK026470 AK291056 BAF83745 AW296249 BC018093 BC019081 AAH19081 BC055427 AAH55427 BC150256 AAI50257 NM_001161560 NP_001155032 NM_001161561 NP_001155033 NM_001161562 NP_001155034 NM_001161563 NP_001155035 NM_001161564 NP_001155036 NM_001161565 NP_001155037 NM_001161566 NP_001155038 NM_015028 NP_055843 NR_027767
Function Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388}.
Subcellular Location Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Tissue Specificity Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:19816403}.

TNIK (C-1) - sc-377215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TNIK (C-1): sc-377215. Western blot analysis of TNIK expression in SK-MEL-28 whole cell lysate.

TNIK (D-16) - sc-100205 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

TNIK (H-80) - sc-98822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TNIK (S-16) - sc-100206 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TNIK (S-16): sc-100206. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic and membrane staining of glandular cells.

TNIK (T-17) - sc-100207 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

TNIK (GA.74) - sc-130445 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TNIK (GA.74): sc-130445. Western blot analysis of TNIK expression in human TNIK transfected (A) and non-transfected (B) 293T whole cell lysates.

TNIK (53) - sc-136103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
TNIK (53): sc-136103. Western blot analysis of TNIK expression in HEK293 whole cell lysate.

p-TNIK (Ser 764) - sc-130221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-TNIK (Ser 764): sc-130221. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

Anti-TNIK (phospho S764) antibody - ab135556 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-fixed, Paraffin-embedded Human hepatocarcinoma tissue labelling TNIK with ab135556 at 1/50 dilution followed by peroxidase-conjugated secondary antibody and AEC staining.

Anti-TNIK (phospho S769) antibody - ab60032 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ab60032 at a dilution of 1/50. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-TNIK antibody - ab150739 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labelled with ab150739 at 2 µg/ml.

Anti-TNIK antibody - ab95887 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TNIK antibody (ab95887) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µg

Anti-TNIK antibody - ab123241 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-TNIK antibody (ab123241) at 1 µg/ml + Mouse spleen lysate at 10 µg

Anti-TNIK antibody - ab56964 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56964 TNIK antibody at 1ug/ml.

Anti-TNIK antibody - ab95888 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of TNIK by Western Blot of Immunprecipitate. anti-TNIK at 1µg/ml staining TNIK in HeLa whole cell lysate immunoprecipitated using ab95888 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-TNIK antibody - ab115619 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115619, at 5µg/ml, staining TNIK in Formalin-fixed, Paraffin-embedded Human skeletal muscle (myocytes) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TNIK Antibody (Internal) IHC-plus™ - LS-A7401 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TNIK antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TNIK Antibody (Internal) IHC-plus™ - LS-A7402 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TNIK antibody LS-A7402 IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TNIK Antibody (aa1-30) - LS-C98728 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-TNIK Antibody (Internal) IHC-plus™ - LS-A7393 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TNIK antibody LS-A7393 IHC of human skeletal muscle, myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TNIK Antibody (Internal) IHC-plus™ - LS-A7403 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TNIK antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TNIK Antibody (N-Terminus) - LS-C328929 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNIK Antibody (phospho-Ser764, APC) - LS-C226511 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNIK Antibody (phospho-Ser764, AP) - LS-C226512 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNIK Antibody (phospho-Ser764, Biotin) - LS-C226513 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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