SATB2
| Gene Symbol | SATB2 |
|---|---|
| Entrez Gene | 23314 |
| Alt Symbol | GLSS |
| Species | Human |
| Gene Type | protein-coding |
| Description | SATB homeobox 2 |
| Other Description | DNA-binding protein SATB2|SATB family member 2|special AT-rich sequence-binding protein 2 |
| Swissprots | Q4V763 Q9UPW6 Q3ZB87 A8K5Z8 |
| Accessions | CAC09123 EAW70180 EAW70181 Q9UPW6 AB028957 BAA82986 AB209376 BAD92613 AJ438951 AK025127 BAB15073 AK056638 BAG51771 AK291463 BAF84152 BC098136 AAH98136 BC099723 AAH99723 BC103492 AAI03493 BC103500 AAI03501 EU446695 ABZ92224 XM_005246396 XP_005246453 XM_006712372 XP_006712435 XM_011510840 XP_011509142 NM_001172509 NP_001165980 NM_001172517 NP_001165988 NM_015265 NP_056080 |
| Function | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. {ECO:0000269|PubMed:14701874}. |
| Subcellular Location | Nucleus matrix {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:14701874}. |
| Tissue Specificity | High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus. {ECO:0000269|PubMed:14701874}. |
SATB2 CRISPR/Cas9 KO Plasmid (h) - sc-418275 from Santa Cruz Biotechnology
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SATB2 HDR Plasmid (h) - sc-418275-HDR from Santa Cruz Biotechnology
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SATB2 Double Nickase Plasmid (h) - sc-418275-NIC from Santa Cruz Biotechnology
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SATB2 Double Nickase Plasmid (h2) - sc-418275-NIC-2 from Santa Cruz Biotechnology
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SATB2 CRISPR Activation Plasmid (h) - sc-418275-ACT from Santa Cruz Biotechnology
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SATB2 CRISPR Activation Plasmid (h2) - sc-418275-ACT-2 from Santa Cruz Biotechnology
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SATB2 Lentiviral Activation Particles (h) - sc-418275-LAC from Santa Cruz Biotechnology
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SATB2 Lentiviral Activation Particles (h2) - sc-418275-LAC-2 from Santa Cruz Biotechnology
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SATB2 siRNA (h) - sc-76456 from Santa Cruz Biotechnology
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SATB2 shRNA Plasmid (h) - sc-76456-SH from Santa Cruz Biotechnology
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SATB2 shRNA (h) Lentiviral Particles - sc-76456-V from Santa Cruz Biotechnology
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SATB2 RNAi - H00023314-R01 from Novus Biologicals
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MISSION® esiRNA - EHU030221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18863 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18863 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11667 from Sigma-Aldrich
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SATB2 siRNA (Human) - CRH8173 from Cohesion Biosciences
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SATB2 - MBS8201702 from MyBioSource
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shRNA set against Human SATB2 (NM_015265.3) - SHH402028 from Creative biogene
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Human SATB2 siRNA - orb268675 from Biorbyt
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SATB2 shRNA Plasmid (Human) - CHH8173 from Cohesion Biosciences
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SATB2 miRNA 3'UTR clone - MiUTR4H-TG07803 from Creative biogene
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