XRN2

Gene Symbol XRN2
Entrez Gene 22803
Alt Symbol -
Species Human
Gene Type protein-coding
Description 5'-3' exoribonuclease 2
Other Description DHP protein|Dhm1-like protein (mouse homolog)
Swissprots Q6KGZ9 Q9NXS6 Q3L8N4 Q9H0D6 Q9BQL1 Q9NTW0 Q9UL53
Accessions EAX10186 EAX10187 Q9H0D6 AF064257 AAD55138 AF152169 AAQ13577 AK000084 BAA90934 AK001573 BAG50941 AK172858 AK302846 BAG64035 AK303312 BAG64381 AK314602 AL136841 CAB66775 AY382900 AAR24369 BC000315 BC006417 AAH06417 BC032075 BC131775 AAI31776 BC142960 BC160100 AAI60100 BF665945 BU620774 CF994999 XM_011529184 XP_011527486 NM_012255 NP_036387
Function Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Tissue Specificity Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. {ECO:0000269|PubMed:10409438, ECO:0000269|PubMed:16147866}.
Top Pathways RNA degradation, Ribosome biogenesis in eukaryotes

XRN2 (D6L5F) Rabbit mAb - 13760 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6L5F
Western blot analysis of extracts from various cell lines using XRN2 (D6L5F) Rabbit mAb.

XRN2 (H-3) - sc-365258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRN2 (H-3): sc-365258. Western blot analysis of XRN2 expression in HEK293 (A) and HeLa (B) whole cell lysates.

XRN2 (H-300) - sc-99237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
XRN2 (H-300): sc-99237. Western blot analysis of XRN2 expression in non-transfected: sc-117752 (A) and human XRN2 transfected: sc-173007 (B) 293T whole cell lysates.

XRN2 (K-20) - sc-50211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRN2 (K-20): sc-50211. Western blot analysis of XRN2 expression in Jurkat (A) and Hep G2 (B) whole cell lysates.

XRN2 (N-20) - sc-50212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRN2 (N-20): sc-50212. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing nuclear staining of glandular cells.

XRN2 (P-17) - sc-50213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRN2 (P-17): sc-50213. Western blot analysis of XRN2 expression in non-transfected: sc-117752 (A) and human XRN2 transfected: sc-173007 (B) 293T whole cell lysates.

Anti-XRN2 antibody - ab72181 from Abcam

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma (left) and mouse teratoma (right) tissues labelling XRN2 with ab72181 at 1/200 (1µg/ml). Detection: DAB.

Anti-XRN2 antibody - ab74408 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab74408, at 1/250 dilution, staining XRN2 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

Anti-XRN2 antibody - ab74799 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab74799 at 1/50 dilution staining XRN2 in human breast carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-XRN2 antibody - ab72284 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRN2 antibody (ab72284) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µg

Anti-XRN2 antibody - ab72307 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRN2 antibody (ab72307) at 0.04 µg/mlLane 1 : Whole cell lysate from HeLa cells at 50 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgLane 5 : Whole cell lysate from NIH 3T3 cells at 50 µg

Anti-XRN2 Antibody (aa1-50) - LS-C90797 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa900-950) - LS-C90799 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa25-75) - LS-C90798 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76, APC) - LS-C218463 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76, Azide-free, HRP) - LS-C218466 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76, FITC) - LS-C218465 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76, Biotin) - LS-C218464 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76, AP) - LS-C218462 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa1-50) - LS-C286040 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76, PE) - LS-C218467 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa25-75) - LS-C287928 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa47-76) - LS-C326401 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRN2 Antibody (aa48-76) - LS-C160675 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
XRN2 Antibody western blot of T47D cell line lysates (35 ug/lane). The XRN2 antibody detected the XRN2 protein (arrow).

Anti-XRN2 Antibody (aa81-130) - LS-C119255 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using XRN2 Antibody. The picture on the right is treated with the synthesized peptide.
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