XRN2

Gene Symbol XRN2
Entrez Gene 22803
Alt Symbol -
Species Human
Gene Type protein-coding
Description 5'-3' exoribonuclease 2
Other Description DHP protein|Dhm1-like protein (mouse homolog)
Swissprots Q6KGZ9 Q9NXS6 Q3L8N4 Q9H0D6 Q9BQL1 Q9NTW0 Q9UL53
Accessions EAX10186 EAX10187 Q9H0D6 AF064257 AAD55138 AF152169 AAQ13577 AK000084 BAA90934 AK001573 BAG50941 AK172858 AK302846 BAG64035 AK303312 BAG64381 AK314602 AL136841 CAB66775 AY382900 AAR24369 BC000315 BC006417 AAH06417 BC032075 BC131775 AAI31776 BC142960 BC160100 AAI60100 BF665945 BU620774 CF994999 XM_011529184 XP_011527486 NM_012255 NP_036387
Function Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
Tissue Specificity Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. {ECO:0000269|PubMed:10409438, ECO:0000269|PubMed:16147866}.
Top Pathways RNA degradation, Ribosome biogenesis in eukaryotes

XRN2 CRISPR/Cas9 KO Plasmid (h) - sc-411608 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 HDR Plasmid (h) - sc-411608-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 Double Nickase Plasmid (h) - sc-411608-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 Double Nickase Plasmid (h2) - sc-411608-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 CRISPR Activation Plasmid (h) - sc-411608-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 CRISPR Activation Plasmid (h2) - sc-411608-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 Lentiviral Activation Particles (h) - sc-411608-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 Lentiviral Activation Particles (h2) - sc-411608-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRN2 siRNA (h) - sc-61813 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRN2 shRNA Plasmid (h) - sc-61813-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRN2 shRNA (h) Lentiviral Particles - sc-61813-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRN2 RNAi - H00022803-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU049051 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22989 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22989 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

XRN2 siRNA (Human) - CRH7782 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XRN2 - MBS8213057 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human XRN2(NM_012255.3) - SHL139260 from Creative biogene

Category siRNA
Species Reactivities Human

XRN2 shRNA Plasmid (Human) - CHH7782 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

XRN2 miRNA 3'UTR clone - MiUTR1H-11326 from Creative biogene

Species Reactivities Human
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