| Gene Symbol |
XRN2
|
| Entrez Gene |
22803
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5'-3' exoribonuclease 2
|
| Other Description |
DHP protein|Dhm1-like protein (mouse homolog)
|
| Swissprots |
Q6KGZ9 Q9NXS6 Q3L8N4 Q9H0D6 Q9BQL1 Q9NTW0 Q9UL53
|
| Accessions |
EAX10186 EAX10187 Q9H0D6 AF064257 AAD55138 AF152169 AAQ13577 AK000084 BAA90934 AK001573 BAG50941 AK172858 AK302846 BAG64035 AK303312 BAG64381 AK314602 AL136841 CAB66775 AY382900 AAR24369 BC000315 BC006417 AAH06417 BC032075 BC131775 AAI31776 BC142960 BC160100 AAI60100 BF665945 BU620774 CF994999 XM_011529184 XP_011527486 NM_012255 NP_036387
|
| Function |
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
|
| Tissue Specificity |
Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. {ECO:0000269|PubMed:10409438, ECO:0000269|PubMed:16147866}.
|
| Top Pathways |
RNA degradation, Ribosome biogenesis in eukaryotes
|