Gene Symbol | OR51E2 |
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Entrez Gene | 81285 |
Alt Symbol | OR51E3P, OR52A2, PSGR |
Species | Human |
Gene Type | protein-coding |
Description | olfactory receptor, family 51, subfamily E, member 2 |
Other Description | HPRAJ|olfactory receptor 51E2|olfactory receptor OR11-16|olfactory receptor, family 51, subfamily E, member 3 pseudogene|olfactory receptor, family 52, subfamily A, member 2|prostate specific G-protein coupled receptor|prostate-specific G-protein coupled receptor |
Swissprots | Q9H255 B2RA63 Q6IF94 |
Accessions | AAG40776 CAJ56785 DAA04766 EAW68829 EAW68831 Q9H255 AF369708 AAK38728 AK314051 BAG36760 AY033942 AAK57550 BC020768 AAH20768 DQ892702 ABM83628 DQ895946 ABM86872 NM_030774 NP_110401 |
Function | Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702). {ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23401498}; Multi-pass membrane protein {ECO:0000269|PubMed:23401498}. |
Tissue Specificity | Mainly expressed in the prostate. Also expressed in spleen, liver, olfactory epithelium and medulla oblongata. {ECO:0000269|PubMed:11707321, ECO:0000269|PubMed:16491480}. |
Top Pathways | Olfactory transduction |
PSGR CRISPR/Cas9 KO Plasmid (h) - sc-405966 from Santa Cruz Biotechnology
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PSGR HDR Plasmid (h) - sc-405966-HDR from Santa Cruz Biotechnology
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PSGR Double Nickase Plasmid (h) - sc-405966-NIC from Santa Cruz Biotechnology
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PSGR Double Nickase Plasmid (h2) - sc-405966-NIC-2 from Santa Cruz Biotechnology
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PSGR CRISPR Activation Plasmid (h) - sc-405966-ACT from Santa Cruz Biotechnology
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PSGR CRISPR Activation Plasmid (h2) - sc-405966-ACT-2 from Santa Cruz Biotechnology
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PSGR Lentiviral Activation Particles (h) - sc-405966-LAC from Santa Cruz Biotechnology
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PSGR Lentiviral Activation Particles (h2) - sc-405966-LAC-2 from Santa Cruz Biotechnology
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PSGR siRNA (h) - sc-76265 from Santa Cruz Biotechnology
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PSGR shRNA Plasmid (h) - sc-76265-SH from Santa Cruz Biotechnology
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PSGR shRNA (h) Lentiviral Particles - sc-76265-V from Santa Cruz Biotechnology
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PSGR RNAi - H00081285-R02 from Novus Biologicals
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MISSION® esiRNA - EHU044941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15969 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15969 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10118 from Sigma-Aldrich
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OR51E2 siRNA (Human) - CRJ2957 from Cohesion Biosciences
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shRNA set against Human OR51E2 (NM_030774.3) - SHH367648 from Creative biogene
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OR51E2 shRNA Plasmid (Human) - CHJ2957 from Cohesion Biosciences
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OR51E2 miRNA 3'UTR clone - MiUTR3H-11762 from Creative biogene
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