HPN

Gene Symbol HPN
Entrez Gene 3249
Alt Symbol TMPRSS1
Species Human
Gene Type protein-coding
Description hepsin
Other Description serine protease hepsin|transmembrane protease serine 1
Swissprots B2RDS4 P05981
Accessions CAC60387 CCQ43929 P05981 AK091988 AK095160 AK293622 BAH11550 AK315655 BAG38021 BC025716 AAH25716 DQ892119 ABM83045 DQ895314 ABM86240 EU644753 ACD02430 M18930 AAA36013 X07002 CAA30058 X07732 CAA30558 XM_005258838 XP_005258895 XM_006723181 XP_006723244 XM_011526891 XP_011525193 NM_002151 NP_002142 NM_182983 NP_892028
Function Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2. {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000269|PubMed:24227843}.
Subcellular Location Membrane; Single-pass type II membrane protein.
Tissue Specificity Present in most tissues, with the highest level in liver.
Top Pathways Viral carcinogenesis

Hepsin (F-18) - sc-18573 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Hepsin (F-18): sc-18573. Western blot analysis of Hepsin expression in c4 (A), NIH/3T3 (B), MDCK (C) and PC-12 (D) whole cell lysates and rat liver (E) and mouse liver (F) tissue extracts.

Hepsin (M-55) - sc-33542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Hepsin (M-55): sc-33542. Western blot analysis of Hepsin expression in WEHI-231 whole cell lysate.

Hepsin (V-16) - sc-18572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Hepsin (V-16): sc-18572. Western blot analysis of Hepsin expression in non-transfected 293T: sc-117752 (A), human Hepsin transfected 293T: sc-114224 (B) and Hep G2 (C) whole cell lysates.

Hepsin (V-15) - sc-47040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Hepsin (V-15): sc-47040. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-Hepsin antibody - ab73133 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Hepsin antibody (ab73133) at 1 µg/ml + HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Hepsin antibody - ab43858 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hepsin antibody (ab43858) at 1/1000 dilutionLane 1 : Tissue lysate prepared from rat kidney Lane 2 : Tissue lysate prepared from rat liver Lane 3 : Tissue lysate prepared from rat lung Lysates/proteins at 5 µl per lane.

Anti-Hepsin antibody - ab31148 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of ab31148 staining in human liver formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab31148, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Hepsin antibody - ab43859 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Hepsin antibody (ab43859) at 1/1000 dilution + Cell media from human embryonic kidney HEK293 cells (treated with IL1-beta)

Anti-Hepsin antibody - ab43860 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hepsin antibody (ab43860) at 1/2500 dilutionLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : SK N BE (Human neuroblastoma) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-Hepsin antibody - ab27765 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Hepsin antibody - ab31149 from Abcam

Host Duck
Clonality Polyclonal

Anti-Hepsin antibody - ab43857 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hepsin antibody (ab43857) at 1/1000 dilutionLane 1 : Rat KidneyLane 2 : Rat LiverLane 3 : Rat Lung

Anti-Hepsin antibody [E4] - ab180045 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone E4

Anti-Hepsin antibody [EP7654] - ab189246 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP7654
Anti-Hepsin antibody [EP7654] (ab189246) at 1/5000 dilution + HepG2 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Hepsin antibody - C-terminal - ab191021 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Hepsin antibody - C-terminal (ab191021) at 0.5 µg/mlLane 1 : 293T cell lysateLane 2 : NRK cell lysateLane 3 : HeLa cell lysateLane 4 : PANC cell lysateLane 5 : MFC-7 cell lysate

Anti-HPN / TMPRSS1 / Hepsin Antibody (clone 2D5) - LS-C197454 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D5
HPN monoclonal antibody (M02), clone 2D5. Western Blot analysis of HPN expression in human liver.

Anti-HPN / TMPRSS1 / Hepsin Antibody (aa46-417) - LS-C67691 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-HPN / TMPRSS1 / Hepsin Antibody (aa163-417) - LS-C123744 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HPN / TMPRSS1 / Hepsin Antibody - LS-C155377 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: HeLa 10% SDS PAGE HPN / Hepsin antibody diluted at 1:2000

Anti-HPN / TMPRSS1 / Hepsin Antibody (aa392-410) - LS-C313162 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of HPN / TMPRSS1 / Hepsin antibody. Lane 1: 293T Cell Lysate. Lane 2: NRK Cell Lysate. Lane 3: HELA Cell Lysate. Lane 4: PANC Cell Lysate. Lane 5: MFC-7 Cell Lysate..

Anti-HPN / TMPRSS1 / Hepsin Antibody IHC-plus™ - LS-B6933 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HPN / Hepsin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6933 concentration 5 ug/ml.

Hepsin Antibody (506230) - MAB47761 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 506230
Hepsin was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human Hepsin Monoclonal Antibody (Catalog # MAB47761) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of hepatocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Hepsin Antibody - AF4776 from Novus Biologicals

Prices $99.00, $369.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of human prostate tissue, human liver tissue, LNCaP human prostate cancer cell line, and PC‑3 human prostate cancer cell line. PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human Hepsin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4776) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Hepsin at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 7.

Hepsin Antibody - NBP1-86931 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Hepsin Antibody [NBP1-86931] - Analysis in control (vector only transfected HEK293T lysate) and HPN over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Hepsin Antibody (506220) - MAB4776 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 506220
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