CHD8

Gene Symbol CHD8
Entrez Gene 57680
Alt Symbol AUTS18, HELSNF1
Species Human
Gene Type protein-coding
Description chromodomain helicase DNA binding protein 8
Other Description ATP-dependent helicase CHD8|axis duplication inhibitor|chromodomain-helicase-DNA-binding protein 8|duplin|helicase with SNF2 domain 1
Swissprots Q8NCY4 Q96F26 Q8TBR9 Q6ZNL7 Q9HCK8 Q6P440 Q4G0D8 Q68DQ0 Q6DKH9 Q8N3Z9
Accessions CCQ43659 EAW66385 Q9HCK8 AB046784 BAB13390 AK056639 AK098408 AK122868 AK122910 AK131077 BAC85127 AL834524 CAD39180 AW327785 BC011695 AAH11695 BC025964 AAH25964 BC036920 AAH36920 BC040636 BC063693 AAH63693 BC073903 AAH73903 BC098452 AAH98452 BC156439 AAI56440 CN290520 CR749315 CAH18170 DA327823 DB344386 U00930 NM_001170629 NP_001164100 NM_020920 NP_065971
Function DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. {ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692}.
Subcellular Location Nucleus {ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:20453063}. Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.
Top Pathways Wnt signaling pathway

Human CHD8 protein fragment - ab153461 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153461 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human CHD8 Protein - H00057680-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CHD8 - H00057680-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CHD8 - H00057680-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Recombinant Human Chromodomain-helicase-DNA-binding protein 8(CHD8) ,partial - CSB-YP872548HU CSB-EP872548HU CSB-BP872548HU CSB-MP872548HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CHD8 Peptide, Human - M34GP03079H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

CHD8 Recombinant Protein Antigen - NBP2-58582PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Chromodomain-helicase-DNA-binding protein 8 (CHD8), partial, Recombinant Protein - MBS1327919 from MyBioSource

Category Protein
Prices $915.00, $915.00, $1,140.00, $1,140.00, $1,300.00, $1,300.00, $1,760.00, $1,760.00, $1,795.00, $2,560.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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