CHD8
| Gene Symbol | CHD8 |
|---|---|
| Entrez Gene | 57680 |
| Alt Symbol | AUTS18, HELSNF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromodomain helicase DNA binding protein 8 |
| Other Description | ATP-dependent helicase CHD8|axis duplication inhibitor|chromodomain-helicase-DNA-binding protein 8|duplin|helicase with SNF2 domain 1 |
| Swissprots | Q8NCY4 Q96F26 Q8TBR9 Q6ZNL7 Q9HCK8 Q6P440 Q4G0D8 Q68DQ0 Q6DKH9 Q8N3Z9 |
| Accessions | CCQ43659 EAW66385 Q9HCK8 AB046784 BAB13390 AK056639 AK098408 AK122868 AK122910 AK131077 BAC85127 AL834524 CAD39180 AW327785 BC011695 AAH11695 BC025964 AAH25964 BC036920 AAH36920 BC040636 BC063693 AAH63693 BC073903 AAH73903 BC098452 AAH98452 BC156439 AAI56440 CN290520 CR749315 CAH18170 DA327823 DB344386 U00930 NM_001170629 NP_001164100 NM_020920 NP_065971 |
| Function | DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1- targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. {ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:20453063}. Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. |
| Top Pathways | Wnt signaling pathway |
CHD8 CRISPR/Cas9 KO Plasmid (h) - sc-404059 from Santa Cruz Biotechnology
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CHD8 HDR Plasmid (h) - sc-404059-HDR from Santa Cruz Biotechnology
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CHD8 Double Nickase Plasmid (h) - sc-404059-NIC from Santa Cruz Biotechnology
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CHD8 Double Nickase Plasmid (h2) - sc-404059-NIC-2 from Santa Cruz Biotechnology
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CHD8 CRISPR Activation Plasmid (h) - sc-404059-ACT from Santa Cruz Biotechnology
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CHD8 CRISPR Activation Plasmid (h2) - sc-404059-ACT-2 from Santa Cruz Biotechnology
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CHD8 Lentiviral Activation Particles (h) - sc-404059-LAC from Santa Cruz Biotechnology
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CHD8 Lentiviral Activation Particles (h2) - sc-404059-LAC-2 from Santa Cruz Biotechnology
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CHD8 siRNA (h) - sc-92413 from Santa Cruz Biotechnology
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CHD8 shRNA Plasmid (h) - sc-92413-SH from Santa Cruz Biotechnology
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CHD8 shRNA (h) Lentiviral Particles - sc-92413-V from Santa Cruz Biotechnology
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CHD8 RNAi - H00057680-R01 from Novus Biologicals
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MISSION® esiRNA - EHU144761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6048 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6048 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03467 from Sigma-Aldrich
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CHD8 siRNA (Human) - CRJ1627 from Cohesion Biosciences
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CHD8 - MBS8219039 from MyBioSource
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shRNA set against Human Chd8 (NM_020920.3) - SHH262913 from Creative biogene
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Human CHD8 siRNA - orb272128 from Biorbyt
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CHD8 shRNA Plasmid (Human) - CHJ1627 from Cohesion Biosciences
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CHD8 miRNA 3'UTR clone - MiUTR3H-11291 from Creative biogene
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