| Gene Symbol |
XPO7
|
| Entrez Gene |
23039
|
| Alt Symbol |
EXP7, RANBP16
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exportin 7
|
| Other Description |
RAN binding protein 16|exportin-7
|
| Swissprots |
Q8NEK7 Q9UIA9 Q6PJK9 O94846
|
| Accessions |
EAW63733 EAW63734 EAW63735 EAW63736 Q9UIA9 AB018288 BAA34465 AF064729 AAF21771 AK291472 BAF84161 AK299848 BAG61710 AK311616 AL597247 BC014219 AAH14219 BC030785 AAH30785 CN479571 DB460798 DC332379 NM_001100161 NM_001100162 NM_015024 NP_055839
|
| Function |
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:11024021, ECO:0000269|PubMed:15282546}.
|
| Subcellular Location |
Cytoplasm. Nucleus {ECO:0000305}. Nucleus, nuclear pore complex {ECO:0000305}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.
|
| Tissue Specificity |
Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. {ECO:0000269|PubMed:11071879, ECO:0000269|PubMed:22509282}.
|