XPO7

Gene Symbol	XPO7
Entrez Gene	23039
Alt Symbol	EXP7, RANBP16
Species	Human
Gene Type	protein-coding
Description	exportin 7
Other Description	RAN binding protein 16|exportin-7
Swissprots	Q8NEK7 Q9UIA9 Q6PJK9 O94846
Accessions	EAW63733 EAW63734 EAW63735 EAW63736 Q9UIA9 AB018288 BAA34465 AF064729 AAF21771 AK291472 BAF84161 AK299848 BAG61710 AK311616 AL597247 BC014219 AAH14219 BC030785 AAH30785 CN479571 DB460798 DC332379 NM_001100161 NM_001100162 NM_015024 NP_055839
Function	Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:11024021, ECO:0000269|PubMed:15282546}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000305}. Nucleus, nuclear pore complex {ECO:0000305}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.
Tissue Specificity	Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. {ECO:0000269|PubMed:11071879, ECO:0000269|PubMed:22509282}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RanBP16 peptide - ab23146 from Abcam Category Peptide Species Human

XPO7 / RANBP16 Antibody Blocking Peptide - LS-E25668 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XPO7 / RANBP16 Antibody Blocking Peptide - LS-E23838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RanBP16 blocking peptide - GTX26041-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Bovine

ranBP16 Peptide - AC21-0498-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Exportin 7 Peptide - 45-558P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

XPO7 fusion protein - Ag3603 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human XPO7, GST-tagged - XPO7-3755H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exportin-7(XPO7) ,partial - CSB-YP887065HU CSB-EP887065HU CSB-BP887065HU CSB-MP887065HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RANBP16/Exportin 7, Peptide - MBS426353 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Pig, Bovine

RanBP16 Recombinant Protein Antigen - NBP2-48800PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

XPO7 Peptide, Human - M34GP17590H from Creative Peptides Category Peptide Source Synthetic. Species Human

RanBP16 Recombinant Protein Antigen - NBP2-48893PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

Exportin-7 (XPO7), partial, Recombinant Protein - MBS1309781 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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