| Gene Symbol |
VAV2
|
| Entrez Gene |
7410
|
| Alt Symbol |
VAV-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vav 2 guanine nucleotide exchange factor
|
| Other Description |
guanine nucleotide exchange factor VAV2|vav 2 oncogene
|
| Swissprots |
Q5SYV5 Q6N012 A2RUM4 P52735 Q6Q317 A8MQ12 B6ZDF5 Q5SYV3 Q5SYV4 Q6PIJ9
|
| Accessions |
EAW88107 EAW88108 EAW88109 P52735 AJ420448 AK091622 AK123314 AK124271 BAC85822 AK130575 AM393013 CAL37891 AM393506 CAL38383 AY563001 AAS75591 BC033187 AAH33187 BC043615 BC128448 BC132965 AAI32966 BC132967 AAI32968 BQ050947 BQ071939 BX640754 CAE45861 S76992 AAB34377 XM_005272213 XP_005272270 XM_006717277 XP_006717340 XM_011518983 XP_011517285 XM_011518984 XP_011517286 NM_001134398 NP_001127870 NM_003371 NP_003362
|
| Function |
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Proteoglycans in cancer, cAMP signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Focal adhesion
|