VAV2

Gene Symbol VAV2
Entrez Gene 7410
Alt Symbol VAV-2
Species Human
Gene Type protein-coding
Description vav 2 guanine nucleotide exchange factor
Other Description guanine nucleotide exchange factor VAV2|vav 2 oncogene
Swissprots Q5SYV5 Q6N012 A2RUM4 P52735 Q6Q317 A8MQ12 B6ZDF5 Q5SYV3 Q5SYV4 Q6PIJ9
Accessions EAW88107 EAW88108 EAW88109 P52735 AJ420448 AK091622 AK123314 AK124271 BAC85822 AK130575 AM393013 CAL37891 AM393506 CAL38383 AY563001 AAS75591 BC033187 AAH33187 BC043615 BC128448 BC132965 AAI32966 BC132967 AAI32968 BQ050947 BQ071939 BX640754 CAE45861 S76992 AAB34377 XM_005272213 XP_005272270 XM_006717277 XP_006717340 XM_011518983 XP_011517285 XM_011518984 XP_011517286 NM_001134398 NP_001127870 NM_003371 NP_003362
Function Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed.
Top Pathways Proteoglycans in cancer, cAMP signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Focal adhesion

Vav2 (C64H2) Rabbit mAb - 2848 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C64H2
Western blot analysis of extracts from various cell types using Vav2 (C64H2) Rabbit mAb.

Vav2 (F-6) - sc-271442 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Vav2 (F-6): sc-271442. Western blot analysis of Vav2 expression in NIH/3T3 whole cell lysate.

Vav2 (E-12) - sc-30433 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Vav2 (H-200) - sc-20803 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Vav2 (H-200): sc-20803. Western blot analysis of Vav2 expression in HeLa (A) and A-431 (B) whole cell lysates and mouse brain tissue extract (C).

Vav2 (K-12) - sc-30432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Vav2 (P-18) - sc-8586 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Vav2 (P-18): sc-8586. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

Vav2 (N-15) - sc-30431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Vav2 (N-15): sc-30431. Western blot analysis of Vav2 expression in HEK293 (A) and MCF7 (B) whole cell lysates.

Vav2 (C-19) - sc-8587 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-VAV2 (phospho Y142) antibody - ab73707 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VAV2 (phospho Y142) antibody (ab73707) at 1/500 dilutionLane 1 : Extracts from K562 cells treated with TNF (200ng/ml, 30mins)Lane 2 : Extracts from Hela cells treated with TNF (200ng/ml, 30mins)Lane 3 : Extracts from K562 cells treated with TNF (200ng/ml, 30mins) plus 5µg immunizing phosphopeptideLysates/proteins at 5 µg per lane.

Anti-VAV2 (phospho Y172) antibody - ab86695 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VAV2 (phospho Y172) antibody (ab86695) at 1/1000 dilutionLane 1 : A431 cells treated with EGFLane 2 : A431 cells treated with EGF, exposed to alkaline phosphatase

Anti-VAV2 antibody - ab79182 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab79182, at a dilution of 1/50, staining VAV2 in paraffin embedded human brain tissue by Immunohistochemistry. Left image: No peptide. Right image: peptide present.

Anti-VAV2 antibody - ab86699 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VAV2 antibody (ab86699) at 1/1000 dilutionLane 1 : A431 cells treated with EGFLane 2 : A431 cells treated with EGF, exposed to alkaline phosphatase

Anti-VAV2 antibody - ab16135 from Abcam

Prices $370.00
Sizes 250 µg
Host Sheep
Clonality Polyclonal

Anti-VAV2 antibody - ab16136 from Abcam

Prices $370.00
Sizes 250 µg
Host Sheep
Clonality Polyclonal

Anti-VAV2 antibody - ab4549 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-VAV2 antibody [EP1067Y] - ab52640 from Abcam

Prices $403.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1067Y
VAV2 was immunoprecipitated using 0.5mg Hek293 whole cell extract, 10µg of Rabbit monoclonal to VAV2 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-). The antibody was incubated under agitation with Protein G beads for 10min, Hek293 whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70oC; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab52640.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 100kDa; VAV2.

Anti-VAV2 antibody [MAC 410] - ab50613 from Abcam

Prices $372.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MAC 410

Anti-VAV2 antibody [MAC 411] - ab50691 from Abcam

Prices $372.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MAC 411

Anti-VAV2 Antibody (aa208-221) IHC-plus™ - LS-B6444 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-VAV2 antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6444 concentration 2.5 ug/ml.

Anti-VAV2 Antibody (C-Terminus) - LS-C11015 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VAV2 Antibody - LS-C26556 from LifeSpan Bioscience

Prices $330.00
Sizes 250 µg
Host Sheep
Clonality Polyclonal
Legend: HEK293 cells were transfected with either empty expression vector (pSR ) or pSRa-Vav2 driving expression of human Vav2. Indicated antibodies (SHD or DPH) were used to immunoprecipitate Vav2 from 300 ug protein lysates. Immunoprecipitated activity was identified by immunoblot of complexes using either DPH (upper gel) or SHD (lower gel) antisera at (1:10000). Immunoprecipitation of Endogenous/Exogenous Vav2 from HEK 283 (75 u g lysate per lane). Top gel - i.p. Ab: DPH or SHD preimmune serum (2.5 l/300 g lysate). DPH or SHD alpha Vav2 antiserum (2.5 l/300 g lysate). Western Blot Ab: DPH anti Vav2 1:10000. Bottom Gel - i.p. Ab DPH or SHD preimmune sera (2.5 l/300 g lysate). DPH or SHD anti Vav2 antisera (2.5 l/300 g lysate). Western blot Ab - SHD anti Vav2 antibody 1:10000.

Anti-VAV2 Antibody (Asp138) - LS-C176997 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of VAV2 (D138) pAb in extracts from THP1 cells.

Anti-VAV2 Antibody - LS-C26557 from LifeSpan Bioscience

Prices $330.00
Sizes 250 µg
Host Sheep
Clonality Polyclonal
Legend: HEK293 cells were transfected with either empty expression vector (pSR ) or pSRa-Vav2 driving expression of human Vav2. Indicated antibodies (SHD or DPH) were used to immunoprecipitate Vav2 from 300 ug protein lysates. Immunoprecipitated activity was identified by immunoblot of complexes using either DPH (upper gel) or SHD (lower gel) antisera at (1:10000). Immunoprecipitation of Endogenous/Exogenous Vav2 from HEK 283 (75 ug lysate per lane). Top gel - i.p. Ab: DPH or SHD preimmune serum (2.5 ul/300 ug lysate). DPH or SHD alpha Vav2 antiserum (2.5 ul/300 ug lysate). Western Blot Ab: DPH anti Vav2 1:10000. Bottom Gel - i.p. Ab DPH or SHD preimmune sera (2.5 ul/300 ug lysate). DPH or SHD anti Vav2 antisera (2.5ul/300 ug lysate). Western blot Ab - SHD anti Vav2 antibody 1:10000.

Anti-VAV2 Antibody (phospho-Tyr142) - LS-C199715 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using VAV2 (Phospho-Tyr142) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-VAV2 Antibody (Ser172, clone EP1067Y) - LS-C49947 from LifeSpan Bioscience

Prices $505.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1067Y
IHC of paraffin-embedded human cervical carcinoma using anti-Vav2 antibody.
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