KCNK3

Gene Symbol	KCNK3
Entrez Gene	3777
Alt Symbol	K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1
Species	Human
Gene Type	protein-coding
Description	potassium channel, two pore domain subfamily K, member 3
Other Description	TWIK-related acid-sensitive K(+) channel 1\|TWIK-related acid-sensitive K+ channel\|acid-sensitive potassium channel protein TASK\|acid-sensitive potassium channel protein TASK-1\|cardiac potassium channel\|potassium channel subfamily K member 3\|potassium inwardly-rectifying channel, subfamily K, member 3\|two P domain potassium channel\|two pore K(+) channel KT3.1\|two pore potassium channel KT3.1
Swissprots	O14649 Q53SU2
Accessions	AAY24312 EAX00678 EAX00679 O14649 AF006823 AAC51777 AF065163 AAG29340 BC140701 AAI40702 XM_005264293 XP_005264350 NM_002246 NP_002237
Function	pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. {ECO:0000269\|PubMed:9312005}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.

TASK-1 (E-13) - sc-32065 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TASK-1 (E-13): sc-32065. Western blot analysis of TASK-1 expression in JAR (A) and JEG-3 (B) whole cell lysates.

TASK-1 (G-13) - sc-32068 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TASK-1 (G-13): sc-32068. Western blot analysis of TASK-1 expression in rat placenta tissue extract (A) and A-10 whole cell lysate (B).

TASK-1 (N-15) - sc-11309 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TASK-1 (H-50) - sc-28635 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

TASK-1 (H-50): sc-28635. Immunofluorescence staining of normal mouse heart frozen section showing membrane staining.

TASK-1 (D-16) - sc-32067 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TASK-1 (D-16): sc-32067. Western blot analysis of TASK-1 expression in JEG-3 whole cell lysate.

Anti-KCNK3 antibody - ab49433 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KCNK3 antibody (ab49433) at 1.25 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-KCNK3 antibody - ab135883 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KCNK3 antibody (ab135883) at 1/500 dilution + JAR cell extracts at 30 µg

Anti-KCNK3 antibody - C-terminal - ab83725 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ICC/IF image of ab83725 stained Panc-1 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab83725 at 5µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 488) - LS-C229382 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48) - LS-C209560 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 565) - LS-C229386 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 390) - LS-C229381 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 594) - LS-C229387 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 655) - LS-C229388 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 680) - LS-C229389 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 633) - LS-C229390 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, AP) - LS-C230151 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Atto 700) - LS-C230150 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, Biotin) - LS-C230153 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, APC) - LS-C230152 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, FITC) - LS-C230154 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (C-Terminus) - LS-C30942 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, PE, Atto 594) - LS-C230156 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, PerCP) - LS-C230157 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

Anti-KCNK3 / OAT1 Antibody (aa251-411, clone S374-48, RPE) - LS-C230158 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	S374-48

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