Gene Symbol | KCNK3 |
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Entrez Gene | 3777 |
Alt Symbol | K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, two pore domain subfamily K, member 3 |
Other Description | TWIK-related acid-sensitive K(+) channel 1|TWIK-related acid-sensitive K+ channel|acid-sensitive potassium channel protein TASK|acid-sensitive potassium channel protein TASK-1|cardiac potassium channel|potassium channel subfamily K member 3|potassium inwardly-rectifying channel, subfamily K, member 3|two P domain potassium channel|two pore K(+) channel KT3.1|two pore potassium channel KT3.1 |
Swissprots | O14649 Q53SU2 |
Accessions | AAY24312 EAX00678 EAX00679 O14649 AF006823 AAC51777 AF065163 AAG29340 BC140701 AAI40702 XM_005264293 XP_005264350 NM_002246 NP_002237 |
Function | pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. {ECO:0000269|PubMed:9312005}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. |
TASK-1 CRISPR/Cas9 KO Plasmid (h) - sc-403477 from Santa Cruz Biotechnology
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TASK-1 HDR Plasmid (h) - sc-403477-HDR from Santa Cruz Biotechnology
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TASK-1 Double Nickase Plasmid (h) - sc-403477-NIC from Santa Cruz Biotechnology
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TASK-1 Double Nickase Plasmid (h2) - sc-403477-NIC-2 from Santa Cruz Biotechnology
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TASK-1 CRISPR Activation Plasmid (h) - sc-403477-ACT from Santa Cruz Biotechnology
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TASK-1 CRISPR Activation Plasmid (h2) - sc-403477-ACT-2 from Santa Cruz Biotechnology
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TASK-1 Lentiviral Activation Particles (h) - sc-403477-LAC from Santa Cruz Biotechnology
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TASK-1 Lentiviral Activation Particles (h2) - sc-403477-LAC-2 from Santa Cruz Biotechnology
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TASK-1 siRNA (h) - sc-42339 from Santa Cruz Biotechnology
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TASK-1 shRNA Plasmid (h) - sc-42339-SH from Santa Cruz Biotechnology
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TASK-1 shRNA (h) Lentiviral Particles - sc-42339-V from Santa Cruz Biotechnology
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KCNK3 RNAi - H00003777-R01 from Novus Biologicals
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KCNK3 siRNA (Human) - CRH2551 from Cohesion Biosciences
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shRNA set against Human KCNK3 (NM_002246.2) - SHH323459 from Creative biogene
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Human KCNK3 siRNA - orb263053 from Biorbyt
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KCNK3 shRNA Plasmid (Human) - CHH2551 from Cohesion Biosciences
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KCNK3 miRNA 3'UTR clone - MiUTR4H-TG04708 from Creative biogene
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