| Gene Symbol |
KCNK3
|
| Entrez Gene |
3777
|
| Alt Symbol |
K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, two pore domain subfamily K, member 3
|
| Other Description |
TWIK-related acid-sensitive K(+) channel 1|TWIK-related acid-sensitive K+ channel|acid-sensitive potassium channel protein TASK|acid-sensitive potassium channel protein TASK-1|cardiac potassium channel|potassium channel subfamily K member 3|potassium inwardly-rectifying channel, subfamily K, member 3|two P domain potassium channel|two pore K(+) channel KT3.1|two pore potassium channel KT3.1
|
| Swissprots |
O14649 Q53SU2
|
| Accessions |
AAY24312 EAX00678 EAX00679 O14649 AF006823 AAC51777 AF065163 AAG29340 BC140701 AAI40702 XM_005264293 XP_005264350 NM_002246 NP_002237
|
| Function |
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. {ECO:0000269|PubMed:9312005}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
|
![Western Blot: KCNK3 Overexpression Lysate (Adult Normal) [NBP2-04220] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNK3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3961_KCNK3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04220-img0001.jpg)