| Gene Symbol |
CNGB3
|
| Entrez Gene |
54714
|
| Alt Symbol |
ACHM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclic nucleotide gated channel beta 3
|
| Other Description |
CNG channel beta-3|cone photoreceptor cGMP-gated cation channel beta-subunit|cyclic nucleotide-gated cation channel beta-3|cyclic nucleotide-gated cation channel modulatory subunit
|
| Swissprots |
Q9NQW8 Q9NRE9 C9JA51
|
| Accessions |
EAW91644 EAW91645 EAW91646 Q9NQW8 AF228520 AAF80179 AF272900 AAF86274 AL713036 BC150601 AAI50602 BX118844 DQ426865 ABD90531 XM_011517138 XP_011515440 NM_019098 NP_061971
|
| Function |
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed specifically in the retina. {ECO:0000269|PubMed:10958649}.
|
| Top Pathways |
cAMP signaling pathway
|
