CNGB3

Gene Symbol	CNGB3
Entrez Gene	54714
Alt Symbol	ACHM1
Species	Human
Gene Type	protein-coding
Description	cyclic nucleotide gated channel beta 3
Other Description	CNG channel beta-3|cone photoreceptor cGMP-gated cation channel beta-subunit|cyclic nucleotide-gated cation channel beta-3|cyclic nucleotide-gated cation channel modulatory subunit
Swissprots	Q9NQW8 Q9NRE9 C9JA51
Accessions	EAW91644 EAW91645 EAW91646 Q9NQW8 AF228520 AAF80179 AF272900 AAF86274 AL713036 BC150601 AAI50602 BX118844 DQ426865 ABD90531 XM_011517138 XP_011515440 NM_019098 NP_061971
Function	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed specifically in the retina. {ECO:0000269|PubMed:10958649}.
Top Pathways	cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CNG-β3 siRNA (h) - sc-45563 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CNG-β3siRNA shRNA Plasmid (h) - sc-45563-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CNG-β3siRNA shRNA (h) Lentiviral Particles - sc-45563-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CNGB3 RNAi - H00054714-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU145301 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2442 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2442 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CNGB3 siRNA (Human) - CRJ0182 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CNGB3 - MBS8213359 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CNGB3 (NM_019098.4) - SHH266213 from Creative biogene Category siRNA Species Reactivities Human

Human CNGB3 siRNA - orb270683 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CNGB3 shRNA Plasmid (Human) - CHJ0182 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CNGB3 miRNA 3'UTR clone - MiUTR4H-TG10927 from Creative biogene Species Reactivities Human

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