| Gene Symbol | GABRG2 |
|---|---|
| Entrez Gene | 2566 |
| Alt Symbol | CAE2, ECA2, GEFSP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
| Other Description | GABA(A) receptor subunit gamma-2|GABA(A) receptor, gamma 2|gamma-aminobutyric acid receptor subunit gamma-2 |
| Swissprots | Q6GRL6 Q9UN15 P18507 Q9UDB3 F5HB82 Q6PCC3 |
| Accessions | AAD50273 EAW61532 EAW61533 EAW61534 EAW61535 P18507 AK123394 AK299640 BAG61563 AK315200 BC036030 BC052926 BC059389 AAH59389 BC069348 AAH69348 BC074795 AAH74795 CD013896 CD013897 DA226729 X15376 CAA33437 NM_000816 NP_000807 NM_198903 NP_944493 NM_198904 NP_944494 |
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:2538761}. |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000269|PubMed:2538761}. Cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000269|PubMed:2538761}. |
| Top Pathways | GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction |