Gene Symbol | GABRG2 |
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Entrez Gene | 2566 |
Alt Symbol | CAE2, ECA2, GEFSP3 |
Species | Human |
Gene Type | protein-coding |
Description | gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
Other Description | GABA(A) receptor subunit gamma-2|GABA(A) receptor, gamma 2|gamma-aminobutyric acid receptor subunit gamma-2 |
Swissprots | Q6GRL6 Q9UN15 P18507 Q9UDB3 F5HB82 Q6PCC3 |
Accessions | AAD50273 EAW61532 EAW61533 EAW61534 EAW61535 P18507 AK123394 AK299640 BAG61563 AK315200 BC036030 BC052926 BC059389 AAH59389 BC069348 AAH69348 BC074795 AAH74795 CD013896 CD013897 DA226729 X15376 CAA33437 NM_000816 NP_000807 NM_198903 NP_944493 NM_198904 NP_944494 |
Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:2538761}. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000269|PubMed:2538761}. Cell membrane {ECO:0000269|PubMed:2538761}; Multi-pass membrane protein {ECO:0000269|PubMed:2538761}. |
Top Pathways | GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction |
GABA A Rγ2 CRISPR/Cas9 KO Plasmid (h) - sc-402057 from Santa Cruz Biotechnology
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GABA A Rγ2 HDR Plasmid (h) - sc-402057-HDR from Santa Cruz Biotechnology
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GABA A Rγ2 Double Nickase Plasmid (h) - sc-402057-NIC from Santa Cruz Biotechnology
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GABA A Rγ2 Double Nickase Plasmid (h2) - sc-402057-NIC-2 from Santa Cruz Biotechnology
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GABA A Rγ2 CRISPR Activation Plasmid (h) - sc-402057-ACT from Santa Cruz Biotechnology
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GABA A Rγ2 CRISPR Activation Plasmid (h2) - sc-402057-ACT-2 from Santa Cruz Biotechnology
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GABA A Rγ2 Lentiviral Activation Particles (h) - sc-402057-LAC from Santa Cruz Biotechnology
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GABA A Rγ2 Lentiviral Activation Particles (h2) - sc-402057-LAC-2 from Santa Cruz Biotechnology
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GABA A Rγ2 siRNA (h) - sc-42449 from Santa Cruz Biotechnology
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GABA A Rγ2 shRNA Plasmid (h) - sc-42449-SH from Santa Cruz Biotechnology
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GABA A Rγ2 shRNA (h) Lentiviral Particles - sc-42449-V from Santa Cruz Biotechnology
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GABA-A R gamma 2 RNAi - H00002566-R03 from Novus Biologicals
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GABA-A R gamma 2 RNAi - H00002566-R02 from Novus Biologicals
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MISSION® esiRNA - EHU083141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9055 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9055 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12861 from Sigma-Aldrich
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GABRG2 siRNA (Human) - CRH1704 from Cohesion Biosciences
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GABA-A R gamma 2 RNAi - H00002566-R01 from Novus Biologicals
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GABRG2 - MBS8213909 from MyBioSource
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shRNA set against Human GABRG2 (NM_000816.3) - SHH298581 from Creative biogene
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Human GABRG2 siRNA - orb262206 from Biorbyt
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GABRG2 shRNA Plasmid (Human) - CHH1704 from Cohesion Biosciences
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