Gene Symbol | UAP1 |
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Entrez Gene | 6675 |
Alt Symbol | AGX, AGX1, AGX2, SPAG2 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-N-acetylglucosamine pyrophosphorylase 1 |
Other Description | UDP-N-acetylhexosamine pyrophosphorylase|antigen X|sperm associated antigen 2|sperm-associated antigen 2 |
Swissprots | Q96GM2 Q5VTA9 Q5VTB0 Q5VTB1 B2R6R8 Q16222 |
Accessions | EAW90710 EAW90711 EAW90712 Q16222 AB011004 BAA31202 AK312685 BAG35565 AW136085 BC009377 AAH09377 CB125476 S73498 AAB31210 XM_005245462 XP_005245519 XM_005245465 XP_005245522 XM_011509913 XP_011508215 XM_011509914 XP_011508216 XM_011509915 XP_011508217 NM_003115 NP_003106 |
Function | Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P. |
Subcellular Location | Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail. |
Tissue Specificity | Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
UAP1 CRISPR/Cas9 KO Plasmid (h) - sc-408705 from Santa Cruz Biotechnology
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UAP1 HDR Plasmid (h) - sc-408705-HDR from Santa Cruz Biotechnology
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UAP1 Double Nickase Plasmid (h) - sc-408705-NIC from Santa Cruz Biotechnology
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UAP1 Double Nickase Plasmid (h2) - sc-408705-NIC-2 from Santa Cruz Biotechnology
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UAP1 CRISPR Activation Plasmid (h) - sc-408705-ACT from Santa Cruz Biotechnology
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UAP1 CRISPR Activation Plasmid (h2) - sc-408705-ACT-2 from Santa Cruz Biotechnology
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UAP1 Lentiviral Activation Particles (h) - sc-408705-LAC from Santa Cruz Biotechnology
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UAP1 Lentiviral Activation Particles (h2) - sc-408705-LAC-2 from Santa Cruz Biotechnology
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UAP1 siRNA (h) - sc-88748 from Santa Cruz Biotechnology
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UAP1 shRNA Plasmid (h) - sc-88748-SH from Santa Cruz Biotechnology
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UAP1 shRNA (h) Lentiviral Particles - sc-88748-V from Santa Cruz Biotechnology
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UAP1 RNAi - H00006675-R01 from Novus Biologicals
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MISSION® esiRNA - EHU085161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22334 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22334 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04395 from Sigma-Aldrich
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UAP1 siRNA (Human) - CRH4552 from Cohesion Biosciences
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UAP1 - MBS8218636 from MyBioSource |
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UAP1 - MBS828383 from MyBioSource |
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shRNA set against Human UAP1 (NM_003115.4) - SHH438612 from Creative biogene
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shRNA set against Human UAP1(NM_003115.4) - SHL109488 from Creative biogene
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Human UAP1 siRNA - orb265054 from Biorbyt
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UAP1 shRNA Plasmid (Human) - CHH4552 from Cohesion Biosciences
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UAP1 miRNA 3'UTR clone - MiUTR1H-10921 from Creative biogene
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