| Gene Symbol |
PLB1
|
| Entrez Gene |
151056
|
| Alt Symbol |
PLB, PLB/LIP, hPLB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase B1
|
| Other Description |
lysophospholipase|phospholipase A2|phospholipase B|phospholipase B/lipase|phospholipase B1, membrane-associated
|
| Swissprots |
Q96DP9 Q53S03 Q6P1J6 Q8IUP7 A8KAX2
|
| Accessions |
AAY24081 AAY24082 EAX00532 EAX00533 EAX00534 EAX00535 EAX00536 Q6P1J6 AK055428 BAB70920 BC042674 AAH42674 BC065041 AAH65041 BC150633 AAI50634 BC153864 AAI53865 BX109719 XM_011532579 XP_011530881 XM_011532580 XP_011530882 XM_011532581 XP_011530883 XM_011532582 XP_011530884 XM_011532583 XP_011530885 XM_011532584 XP_011530886 XM_011532585 XP_011530887 XM_011532586 XP_011530888 XM_011532587 XP_011530889 XM_011532588 XP_011530890 XM_011532589 XP_011530891 XM_011532590 XP_011530892 XM_011532591 XP_011530893 XM_011532592 XP_011530894 XM_011532593 XP_011530895 XM_011532594 XP_011530896 XM_011532595 XP_011530897 XM_011532596 XP_011530898 XM_011532597 XP_011530899 XM_011532598 XP_011530900 XM_011532599 XP_011530901 XM_011532600 XP_011530902 XM_011532601 XP_011530903 XM_011532602 XP_011530904 XM_011532603 XP_011530905 XM_011532604 XP_011530906 XM_011532605 XP_011530907 XM_011532606 XP_011530908 XM_011532607 XP_011530909 XM_011532608 XP_011530910 XM_011532609 XP_011530911 XM_011532610 XP_011530912 XM_011532611 XP_011530913 XM_011532612 XP_011530914 XR_939661 XR_939662 XR_939663 XR_939664 XR_939665 XR_939666 XR_939667 NM_001170585 NP_001164056 NM_153021 NP_694566
|
| Function |
Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Present in the intestinal brush border membranes. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the epidermis (at protein level). {ECO:0000269|PubMed:12150957}.
|
| Top Pathways |
Vitamin digestion and absorption, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism
|