| Gene Symbol |
EPHB2
|
| Entrez Gene |
2048
|
| Alt Symbol |
CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EPH receptor B2
|
| Other Description |
EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protein kinase receptor EPH-3
|
| Swissprots |
Q5T0U7 O43477 Q5T0U8 Q5T0U6 P29323
|
| Accessions |
CAA41981 CAD83767 CAT16948 EAW95022 EAW95023 EAW95024 EAW95025 EAW95026 P29323 AB210018 BAE06100 AF025304 AAB94602 AK298898 BAG61009 AK299701 BAG61602 AL530874 BC007903 BC018763 BC041017 BC067861 AAH67861 BC146296 AAI46297 BQ641281 D14717 BAA03537 D31661 BAA06506 D37827 BAA07073 HM437237 ADN43068 L36643 AAA74244 L41939 AAA99310 XM_006710441 XP_006710504 XM_006710442 XP_006710505 XM_011540976 XP_011539278 NM_004442 NP_004433 NM_017449 NP_059145
|
| Function |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
|
| Tissue Specificity |
Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
|
| Top Pathways |
Axon guidance
|
