EPHB2

Gene Symbol EPHB2
Entrez Gene 2048
Alt Symbol CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Species Human
Gene Type protein-coding
Description EPH receptor B2
Other Description EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protein kinase receptor EPH-3
Swissprots Q5T0U7 O43477 Q5T0U8 Q5T0U6 P29323
Accessions CAA41981 CAD83767 CAT16948 EAW95022 EAW95023 EAW95024 EAW95025 EAW95026 P29323 AB210018 BAE06100 AF025304 AAB94602 AK298898 BAG61009 AK299701 BAG61602 AL530874 BC007903 BC018763 BC041017 BC067861 AAH67861 BC146296 AAI46297 BQ641281 D14717 BAA03537 D31661 BAA06506 D37827 BAA07073 HM437237 ADN43068 L36643 AAA74244 L41939 AAA99310 XM_006710441 XP_006710504 XM_006710442 XP_006710505 XM_011540976 XP_011539278 NM_004442 NP_004433 NM_017449 NP_059145
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm
Subcellular Location Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Top Pathways Axon guidance

EphB2 CRISPR/Cas9 KO Plasmid (h) - sc-401642 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 HDR Plasmid (h) - sc-401642-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 Double Nickase Plasmid (h) - sc-401642-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 Double Nickase Plasmid (h2) - sc-401642-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 CRISPR Activation Plasmid (h) - sc-401642-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 CRISPR Activation Plasmid (h2) - sc-401642-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 Lentiviral Activation Particles (h) - sc-401642-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 Lentiviral Activation Particles (h2) - sc-401642-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphB2 siRNA (h) - sc-39949 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EphB2 shRNA Plasmid (h) - sc-39949-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EphB2 shRNA (h) Lentiviral Particles - sc-39949-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EphB2 RNAi - H00002048-R08 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU060511 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK0713 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0711 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0712 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1138 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1138 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12754 from Sigma-Aldrich

Category miRNA

EPHB2 siRNA (Human) - CRH1425 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EphB2 RNAi - H00002048-R07 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EPHB2 - MBS8230079 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Ephb2 (NM_004442.6) - SHH286453 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human EPHB2(NM_004442.6) - SHH036281 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human EPHB2(NM_017449.3) - SHH036299 from Creative biogene

Category siRNA
Species Reactivities Human
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